Document Detail

Chemiluminescence derivatization of methylglyoxal using 2-aminonicotinic acid.
MedLine Citation:
PMID:  10959598     Owner:  NLM     Status:  MEDLINE    
To develop a sensitive and selective chemiluminometric method for the determination of methylglyoxal, we used 2-aminonicotinic acid as the chemiluminescence derivatization reagent. 2-Aminonicotinic acid reacts with methylglyoxal in an acidic solution at 37 degrees C for 4 h and gave a chemiluminescence in N,N'-dimethylformamide containing sodium tert-butoxide. The detection limit (blank intensity plus three-times its standard deviation of methylglyoxal) for methylglyoxal is 233 fmol in the reaction mixture.
Y Ohba; M Sakata; K Zaitsu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  48     ISSN:  0009-2363     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-12-04     Completed Date:  2000-12-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1236-8     Citation Subset:  IM    
Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi, Fukuoka, Japan.
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MeSH Terms
Chemiluminescent Measurements
Nicotinic Acids / chemistry*
Pyruvaldehyde / chemistry*
Reg. No./Substance:
0/Nicotinic Acids; 5345-47-1/2-aminonicotinic acid; 78-98-8/Pyruvaldehyde

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