| Chemically tunable electrochemical dissolution of noncontinuous polyelectrolyte assemblies: an in situ study using ecAFM. | |
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MedLine Citation:
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PMID: 21067205 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The electrochemically triggered dissolution of noncontinuous polyelectrolyte assemblies presenting distinct nanomorphologies and its tuning by chemical cross-linking were monitored locally, in situ, by electrochemical atomic force microscopy. Poly-l-lysine and hyaluronic acid deposited layer-by-layer on indium tin oxide electrodes at specific experimental conditions formed well-defined nanostructures whose morphologies could be easily and precisely followed along the dissolution process. In addition to shrinkage of polyelectrolyte nanodroplets, ecAFM images revealed the faster dissolution of coalesced structures compared to droplet-like complexes, and the readsorption of dissolved polyelectrolytes onto slower dissolving neighboring structures. Covalently cross-linked PLL/HA assemblies dissolved only partially, and exhibited slower dissolution rates compared to native multilayers, with a clear dependence on the cross-link density. Tuning the electrochemical dissolution of polyelectrolyte multilayers through chemical cross-linking opens new prospects for future biomedical applications, such as the development of advanced drug or gene delivery platforms allowing for tightly controlled releases of different compounds at specific rates. |
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Authors:
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Orane Guillaume-Gentil; Daniele Abbruzzese; Elsa Thomasson; Janos Vörös; Tomaso Zambelli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-10 |
Journal Detail:
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Title: ACS applied materials & interfaces Volume: 2 ISSN: 1944-8244 ISO Abbreviation: ACS Appl Mater Interfaces Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504991 Medline TA: ACS Appl Mater Interfaces Country: United States |
Other Details:
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Languages: eng Pagination: 3525-31 Citation Subset: IM |
Affiliation:
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Laboratory of Biosensors and Bioelectronics, Institute for Biomedical Engineering, ETH and University Zurich, Gloriastrasse 35, 8092 Zurich, Switzerland. guillaume@biomed.ee.ethz.ch |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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