Document Detail


Chemically Reducible Lipid Bilayer Coated Mesoporous Silica Nanoparticles Demonstrating Controlled Release and HeLa and Normal Mouse Liver Cell Biocompatibility and Cellular Internalization.
MedLine Citation:
PMID:  22738645     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A controlled release system comprised of mesoporous silica nanoparticles with covalently bound dipalmitoyl moieties supporting phosphorylated lipids (LB-MSN) has been successfully synthesized, characterized and demonstrated controlled release of fluorescein molecules under disulfide reducing conditions. Flow cytometry analyses confirm improved biocompatibility of the resulting lipid bilayer MSN (LB-MSN) from nonfunctional MSN. Fluorescently labeled LB-MSNs are examined via confocal fluorescent microscopy in vivo and were found to enter both normal and cancer cell lines. The LB-MSNs presented here have potential to be used as rapid and diverse functionalized, stable liposome analogues for drug delivery.
Authors:
Robert A Roggers; Brian G Trewyn
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  Molecular pharmaceutics     Volume:  -     ISSN:  1543-8392     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101197791     Medline TA:  Mol Pharm     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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