| Chemically Reducible Lipid Bilayer Coated Mesoporous Silica Nanoparticles Demonstrating Controlled Release and HeLa and Normal Mouse Liver Cell Biocompatibility and Cellular Internalization. | |
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MedLine Citation:
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PMID: 22738645 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A controlled release system comprised of mesoporous silica nanoparticles with covalently bound dipalmitoyl moieties supporting phosphorylated lipids (LB-MSN) has been successfully synthesized, characterized and demonstrated controlled release of fluorescein molecules under disulfide reducing conditions. Flow cytometry analyses confirm improved biocompatibility of the resulting lipid bilayer MSN (LB-MSN) from nonfunctional MSN. Fluorescently labeled LB-MSNs are examined via confocal fluorescent microscopy in vivo and were found to enter both normal and cancer cell lines. The LB-MSNs presented here have potential to be used as rapid and diverse functionalized, stable liposome analogues for drug delivery. |
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Authors:
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Robert A Roggers; Brian G Trewyn |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-6-27 |
Journal Detail:
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Title: Molecular pharmaceutics Volume: - ISSN: 1543-8392 ISO Abbreviation: - Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-6-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197791 Medline TA: Mol Pharm Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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