Document Detail

Chemical synthesis and in vitro biocompatibility tests of poly (L-lactic acid).
MedLine Citation:
PMID:  17437300     Owner:  NLM     Status:  MEDLINE    
Polylactic acid is a polymer of great technological interest, whose excellent mechanical properties, thermal plasticity, and bioresorbability render it potentially useful for environmental applications, as a biodegradable plastic and as a biocompatible material in biomedicine. This article discusses the synthesis and characterization of poly-L-lactic acid, obtained through two synthetic routes: direct polycondensation reactions without organic solvents, and in a supercritical medium. Tin complexes were used as catalysts in both polymerization reactions. The polymers were characterized by (1)HNMR, IR, GPC, DSC, and TGA techniques. In vitro biocompatibility tests were performed with human alveolar bone osteoblasts and there were assessed cell adhesion, proliferation and viability. The poly condensation reaction proved to be an excellent synthetic route to produce PLA polymers with different molar mass. The formation of polymers from lactic acid monomer was confirmed through techniques utilized. It was observed that cell adhesion and viability was not disturbed by the presence of the polymer, although the proliferation rate was decreased when compared to control.
Vanusca Dalosto Jahno; Gabriela Benderóvicz Mendes Ribeiro; Luís Alberto dos Santos; Rosane Ligabue; Sandra Einloft; Maidy Rehder Wimmers Ferreira; Karina Fittipaldi Bombonato-Prado
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical materials research. Part A     Volume:  83     ISSN:  1549-3296     ISO Abbreviation:  -     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234237     Medline TA:  J Biomed Mater Res A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  209-15     Citation Subset:  IM    
Materials Engineering-UFRGS, Av. Bento Gonçalves 9500, Setor IV-Edif. 74-123, 91501-970 Porto Alegre, Brazil.
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MeSH Terms
Biocompatible Materials / chemical synthesis*,  pharmacology
Calorimetry, Differential Scanning
Cell Proliferation / drug effects
Cell Survival / drug effects
Cells, Cultured
Chromatography, Gel
Culture Media, Conditioned
Lactic Acid / chemical synthesis*,  chemistry,  pharmacology
Magnetic Resonance Spectroscopy
Materials Testing / methods*
Osteoblasts / cytology,  drug effects
Polymers / chemical synthesis*,  chemistry,  pharmacology
Spectrophotometry, Infrared
Reg. No./Substance:
0/Biocompatible Materials; 0/Culture Media, Conditioned; 0/Polymers; 0/Protons; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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