| Chemical synthesis and in vitro biocompatibility tests of poly (L-lactic acid). | |
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MedLine Citation:
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PMID: 17437300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Polylactic acid is a polymer of great technological interest, whose excellent mechanical properties, thermal plasticity, and bioresorbability render it potentially useful for environmental applications, as a biodegradable plastic and as a biocompatible material in biomedicine. This article discusses the synthesis and characterization of poly-L-lactic acid, obtained through two synthetic routes: direct polycondensation reactions without organic solvents, and in a supercritical medium. Tin complexes were used as catalysts in both polymerization reactions. The polymers were characterized by (1)HNMR, IR, GPC, DSC, and TGA techniques. In vitro biocompatibility tests were performed with human alveolar bone osteoblasts and there were assessed cell adhesion, proliferation and viability. The poly condensation reaction proved to be an excellent synthetic route to produce PLA polymers with different molar mass. The formation of polymers from lactic acid monomer was confirmed through techniques utilized. It was observed that cell adhesion and viability was not disturbed by the presence of the polymer, although the proliferation rate was decreased when compared to control. |
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Authors:
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Vanusca Dalosto Jahno; Gabriela Benderóvicz Mendes Ribeiro; Luís Alberto dos Santos; Rosane Ligabue; Sandra Einloft; Maidy Rehder Wimmers Ferreira; Karina Fittipaldi Bombonato-Prado |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of biomedical materials research. Part A Volume: 83 ISSN: 1549-3296 ISO Abbreviation: - Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-08-20 Completed Date: 2007-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101234237 Medline TA: J Biomed Mater Res A Country: United States |
Other Details:
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Languages: eng Pagination: 209-15 Citation Subset: IM |
Affiliation:
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Materials Engineering-UFRGS, Av. Bento Gonçalves 9500, Setor IV-Edif. 74-123, 91501-970 Porto Alegre, Brazil. vanuscadalosto@yahoo.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biocompatible Materials
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chemical synthesis*,
pharmacology Calorimetry, Differential Scanning Cell Proliferation / drug effects Cell Survival / drug effects Cells, Cultured Chromatography, Gel Culture Media, Conditioned Humans Lactic Acid / chemical synthesis*, chemistry, pharmacology Magnetic Resonance Spectroscopy Materials Testing / methods* Osteoblasts / cytology, drug effects Polymers / chemical synthesis*, chemistry, pharmacology Protons Spectrophotometry, Infrared Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Culture Media, Conditioned; 0/Polymers; 0/Protons; 26100-51-6/poly(lactic acid); 50-21-5/Lactic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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