Document Detail

Chemical structure and selected biological properties of a glucomannan from the lichenized fungus Heterodermia obscurata.
MedLine Citation:
PMID:  20947106     Owner:  NLM     Status:  In-Process    
Successive aqueous and alkaline extraction of the thallus of the lichenized fungus Heterodermia obscurata provided a highly branched glucomannan fraction (GM), whose chemical structure was determined. This was based on monosaccharide composition, methylation, partial acid hydrolysis, and NMR spectroscopic analysis. It consisted of a main chain of (1→6)-linked α-D-mannopyranosyl units, almost all being substituted at O-2 with α-D-glucopyranosyl, α-D-mannopyranosyl, and 4-O-substituted α-D-mannopyranosyl groups. Intra-peritoneal administration of this GM induced a marked and dose-dependent inhibition of acetic acid-induced visceral pain with an ID(50) of 0.6 (0.2-2.0) mg/kg and inhibition of 88±4%. It also reduced leukocyte migration by 58±4%, but did not alter plasmatic extravasation to the peritoneal cavity. The results suggest that the glucomannan from the H. obscurata might have potential for antinociceptive and anti-inflammatory utilization.
Maria Izabel Pereira; Andrea Caroline Ruthes; Elaine R Carbonero; Rodrigo Marcon; Cristiane H Baggio; Cristina S Freitas; Adair Roberto S Santos; Sionara Eliasaro; Guilherme L Sassaki; Philip Albert J Gorin; Marcello Iacomini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-12
Journal Detail:
Title:  Phytochemistry     Volume:  71     ISSN:  1873-3700     ISO Abbreviation:  Phytochemistry     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151434     Medline TA:  Phytochemistry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2132-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Departamento de Farmácia, Faculdade Assis Gurgacz, 85806-090 Cascavel, PR, Brazil.
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