Document Detail


Chemical structure and immunoinhibitory activity of a pectic polysaccharide containing glucuronic acid from the leaves of Diospyros kaki.
MedLine Citation:
PMID:  20361992     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pectin is a family of complex polysaccharides characterized by the presence of 1,4-linked alpha-galacturonic acid residues in the backbone and is more recognized for its potential bioactive properties. Herein we reported the structural and biological features of a pectic fraction DL-4OAC-1 from the leaves of Diospyros kaki. Chemical and spectral analysis revealed this polysaccharide possessed a backbone composed of a repeating disaccharide [-->4)-alpha-GalAp-(1-->2)-alpha-Rhap-(1-->], substituted at some O-4 of Rhap residues and O-3 of GalAp residues by the side chains consisting of Araf, Galp, Xylp, and in particular terminal GlcAp residues. The immunological assay in vitro showed that this distinct pectic fraction could inhibit the LPS-induced B lymphocyte proliferation and had no effect on the ConA-induced T lymphocyte proliferation.
Authors:
Jinyou Duan; Vincent L Chen; Qun Dong; Kan Ding; Jinian Fang
Publication Detail:
Type:  Journal Article     Date:  2010-03-31
Journal Detail:
Title:  International journal of biological macromolecules     Volume:  46     ISSN:  1879-0003     ISO Abbreviation:  Int. J. Biol. Macromol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909578     Medline TA:  Int J Biol Macromol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  465-70     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Affiliation:
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, People's Republic of China. jduan@rics.bwh.harvard.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbohydrate Conformation
Cell Proliferation / drug effects
Diospyros / chemistry*
Glucuronic Acid / chemistry*
Hydrolysis / drug effects
Immunologic Factors / chemistry*,  pharmacology*
Lymphocytes / cytology,  drug effects
Magnetic Resonance Spectroscopy
Methylation / drug effects
Mice
Mice, Inbred C57BL
Mitogens / pharmacology
Plant Leaves / chemistry*
Polysaccharides / chemistry*,  pharmacology*
Spectrometry, Mass, Electrospray Ionization
Chemical
Reg. No./Substance:
0/Immunologic Factors; 0/Mitogens; 0/Polysaccharides; 576-37-4/Glucuronic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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