Document Detail


Chemical structure and biological activity of polysaccharides from Hibiscus sabdariffa.
MedLine Citation:
PMID:  1620746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three water-soluble polysaccharides have been isolated from flower buds of Hibiscus sabdariffa L. (HIB 1,2,3). The neutral polysaccharides (HIB 1 and 2) are composed of arabinans and arabinogalactans of low relative molecular mass. The major fraction was investigated by methylation analysis, pectinase-treatment, mild acid hydrolysis and NMR studies, and it was shown to be a pectin-like molecule (Mr = 10(5)d). The main chain is composed of alpha-1,4-linked GalA (24% methyl-esterified) and alpha-1,2-linked Rha. Side chains are built of Gal and Ara and are connected to the main chain via C-4 of every third Rha. Its structure seems to be different from polysaccharide structures described in other species of the Hibiscus genus and the Malvaceae family. All fractions were assayed for possible immune-modulating effects. All fractions showed some activity, but the main acidic fraction was contaminated with lipopolysaccharide, and therefore its shown activity has to be discussed carefully.
Authors:
B M Müller; G Franz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  58     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-08-04     Completed Date:  1992-08-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  60-7     Citation Subset:  IM    
Affiliation:
Faculty of Pharmacy, University of Regensburg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification,  pharmacology*
Cells, Cultured
Drug Screening Assays, Antitumor
Female
Mice
Mice, Inbred C3H
Mitogens / chemistry,  isolation & purification,  pharmacology
Molecular Structure
Plants / chemistry*
Polysaccharides / chemistry,  isolation & purification,  pharmacology*
Sarcoma 180 / drug therapy
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Mitogens; 0/Polysaccharides

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