| Review: Chemical and structural modifications of pulmonary collectins and their functional consequences. | |
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MedLine Citation:
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PMID: 20423921 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The lung is continuously exposed to inhaled pathogens (toxic pollutants, micro-organisms, environmental antigens, allergens) from the external environment. In the broncho-alveolar space, the critical balance between a measured protective response against harmful pathogens and an inappropriate inflammatory response to harmless particles is discerned by the innate pulmonary immune system. Among its many components, the surfactant proteins and specifically the pulmonary collectins (surfactant proteins A [SP-A] and D [SP-D]) appear to provide important contributions to the modulation of host defense and inflammation in the lung. Many studies have shown that multimerization of SP-A and SP-D are important for efficient local host defense including neutralization and opsonization of influenza A virus, binding Pneumocystis murina and inhibition of LPS-induced inflammatory cell responses. These observations strongly imply that oligomerization of collectins is a critical feature of its function. However, during the inflammatory state, despite normal pool sizes, chemical modification of collectins can result in alteration of their structure and function. Both pulmonary collectins can be altered through proteolytic inactivation, nitration, S-nitrosylation, oxidation and/or crosslinking as a consequence of the inflammatory milieu facilitated by cytokines, nitric oxide, proteases, and other chemical mediators released by inflammatory cells. Thus, this review will summarize recent developments in our understanding of the relationship between post-translational assembly of collectins and their modification by inflammation as an important molecular switch for the regulation of local innate host defense. |
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Authors:
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Elena N Atochina-Vasserman; Michael F Beers; Andrew J Gow |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2010-04-27 |
Journal Detail:
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Title: Innate immunity Volume: 16 ISSN: 1753-4267 ISO Abbreviation: Innate Immun Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-11-03 Revised Date: 2011-09-14 |
Medline Journal Info:
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Nlm Unique ID: 101469670 Medline TA: Innate Immun Country: United States |
Other Details:
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Languages: eng Pagination: 175-82 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA. atochina@mail.med.upenn.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Agglutination Animals Bacterial Adhesion Collectins / chemistry, immunology, metabolism* Humans Immunity, Innate Immunomodulation Inflammation Mediators / chemistry, immunology, metabolism* Influenza A virus / immunology* Lung / immunology* Mice Pneumocystis / immunology* Protein Multimerization Protein Processing, Post-Translational |
| Grant Support | |
ID/Acronym/Agency:
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ES P30-013508/ES/NIEHS NIH HHS; ES-005022/ES/NIEHS NIH HHS; HL-074115/HL/NHLBI NIH HHS; HL-64520/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Collectins; 0/Inflammation Mediators |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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