Document Detail

Chemical sterilization with an IUD.
MedLine Citation:
PMID:  12336997     Owner:  PIP     Status:  MEDLINE    
Zipper has more than adequately demonstrated that quinacrine, when placed in the uterine cavity, has a sclerosing effect on the tubal ostia, resulting in chemical sterilization of the fallopian tubes. His technique involves the use of 3 monthly instillations of 250 mg of pellets into the uterine cavity. With the hope of reducing the total dosage and making it a 1-insertion technique, quinacrine has been mixed with polyethylene oxide and place on the arms of various IUDs. It is hoped that the material is directed at the tubal ostia. Studies to date have occurred in women awaiting hysterectomy with careful pathologic examination of the intramural portion of the tube. The results thus far are most encouraging and once the best vector is identified, it is hoped that this will become an acceptable means of female sterilization.
L E Laufe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contraceptive delivery systems     Volume:  2     ISSN:  0143-6112     ISO Abbreviation:  Contracept Deliv Syst     Publication Date:  1981 Oct 
Date Detail:
Created Date:  1982-02-09     Completed Date:  1982-02-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8102096     Medline TA:  Contracept Deliv Syst     Country:  United States    
Other Details:
Languages:  eng     Pagination:  343-7     Citation Subset:  J    
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MeSH Terms
Chemical Phenomena
Family Planning Services
General Surgery
Gynecologic Surgical Procedures*
Intrauterine Devices*
Pharmaceutical Preparations
Sterilization, Reproductive*
Sterilization, Tubal*
Reg. No./Substance:
0/Chemosterilants; 0/Pharmaceutical Preparations; 0/Polymers; 83-89-6/Quinacrine; 9002-88-4/Polyethylene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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