Document Detail


Chemical stability and mode of gastrointestinal absorption of sodium monofluorophosphate.
MedLine Citation:
PMID:  3365276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sodium monofluorophosphate, an agent used for the fluorine therapy of osteoporosis, is chemically stable in aqueous environment in the range from pH 13 to 2. At pH lower than 1.5 the monofluorophosphate ion (MFP) hydrolyzes to fluoride and orthophosphate. At these pH values fluoride forms undissociated hydrofluoric acid which damages the gastric mucosa. Therefore, to prevent the formation of hydrofluoric acid, sodium monofluorophosphate should always be combined with buffering agents, preferably calcium salts, because calcium is compatible with MFP and is an aid for osteoporosis. MFP is stable in the intestinal environment. It is absorbed from the gastrointestinal lumen and is then hydrolyzed into fluoride and orthophosphate. Hydrolysis is provided by MFPases of the intestinal mucosa and of the liver. Alkaline phosphatase has MFPase activity, whereas acid phosphatase has not. In conclusion, if buffered with an appropriate calcium salt, MFP is stable in the gastrointestinal environment and does not release fluoride which could damage the gastrointestinal mucosa and be sequestrated by calcium ions of the diet or given as medicaments.
Authors:
I Setnikar; R Arigoni
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Arzneimittel-Forschung     Volume:  38     ISSN:  0004-4172     ISO Abbreviation:  Arzneimittelforschung     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-06-02     Completed Date:  1988-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372660     Medline TA:  Arzneimittelforschung     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  45-9     Citation Subset:  IM    
Affiliation:
Rotta Research Laboratorium, Monza, Italy.
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MeSH Terms
Descriptor/Qualifier:
Alkaline Phosphatase / metabolism
Animals
Drug Stability
Erythrocytes / metabolism
Fluorides / pharmacokinetics*
Gastric Juice / metabolism
Hydrogen-Ion Concentration
Hydrolysis
Intestinal Absorption
Intestine, Small / metabolism
Male
Phosphates / pharmacokinetics*
Rats
Rats, Inbred Strains
Sodium Fluoride / metabolism
Stomach / metabolism
Chemical
Reg. No./Substance:
0/Fluorides; 0/Phosphates; 15181-43-8/fluorophosphate; 7681-49-4/Sodium Fluoride; EC 3.1.3.1/Alkaline Phosphatase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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