| Chemical mediators of the muscle ergoreflex in chronic heart failure: a putative role for prostaglandins in reflex ventilatory control. | |
| | |
MedLine Citation:
|
PMID: 12105161 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The overactivity of ergoreceptors (intramuscular afferents sensitive to products of skeletal muscle work) may be responsible for the abnormal responses to exercise and symptoms of exercise intolerance in chronic heart failure (CHF); however, little is known of the chemical nature of the stimuli involved. We investigated biochemical factors (H+, VCO2, VO2, HCO3, K+, phosphate, lactate, PGE2, PGF(1alpha), and bradykinin) potentially involved in ergoreceptor activation. METHODS AND RESULTS: Sixteen stable patients with CHF (64.9+/-2.7 years, peak VO2 15.8+/-0.7 mL/kg per min) and 10 age-matched controls were studied. The ergoreceptor test involved two 5-minute handgrip exercises. On one occasion, the subjects recovered normally (control recovery), whereas on the other a posthandgrip regional circulatory occlusion was induced in the exercising arm, isolating the stimulation of the ergoreceptor after exercise. The ergoreflex was quantified as the difference in ventilation between the posthandgrip regional circulatory occlusion and the control recovery periods. During the protocol, the local muscular blood effluent concentrations of metabolic mediators were assessed. Patients had an ergoreflex effect on ventilation greater than controls (4.8+/-1.4 versus 0.4+/-0.1 L/min, P<0.01). During the ergoreflex test in patients, the following metabolites were elevated with respect to resting values in comparison with controls: PGE2 (3.7+/-0.7 versus 1.1+/-0.2 pg/mL), PGF(1alpha) (16.2+/-2.8 versus 7.2+/-1.2 pg/mL), and bradykinin (2.1+/-0.3 versus 1.0+/-0.1 pg/mL), P<0.05 for all comparisons. Only the increases in prostaglandins were predictors of the ergoreflex response (r>0.41, P<0.01). CONCLUSIONS: Although multiple metabolites are concentrated in exercising muscle in CHF, only prostaglandins correlated with ergoreflex activity, suggesting these factors as potential triggers to the exaggerated ergoreflex, which is characteristic of CHF. This may have important implications for novel therapies to improve exercise tolerance. |
| | |
Authors:
|
Adam C Scott; Roland Wensel; Constantinos H Davos; Michael Kemp; Agnieszka Kaczmarek; James Hooper; Andrew J S Coats; Massimo F Piepoli |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulation Volume: 106 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 2002 Jul |
Date Detail:
|
Created Date: 2002-07-09 Completed Date: 2002-07-19 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: United States |
Other Details:
|
Languages: eng Pagination: 214-20 Citation Subset: AIM; IM |
Affiliation:
|
National Heart & Lung Institute, and Royal Brompton Hospital, Imperial College School of Science, Technology and Medicine, London, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aspirin / pharmacology Bradykinin / blood Chemoreceptor Cells / metabolism Chronic Disease Cyclooxygenase Inhibitors / pharmacology Exercise* Exercise Test Female Hand Heart Failure / blood, diagnosis, physiopathology* Humans Kinetics Lactic Acid / blood Male Middle Aged Muscle, Skeletal / blood supply, physiopathology* Myocardial Ischemia / blood, diagnosis, physiopathology Prostaglandins / blood, physiology* Protons Pulmonary Ventilation Reflex / physiology* |
| Chemical | |
Reg. No./Substance:
|
0/Cyclooxygenase Inhibitors; 0/Prostaglandins; 0/Protons; 50-21-5/Lactic Acid; 50-78-2/Aspirin; 58-82-2/Bradykinin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Platelet nitric oxide and superoxide release during the development of nitrate tolerance: effect of ...
Next Document: Allopurinol improves endothelial dysfunction in chronic heart failure.