Document Detail

Chemical leucoderma: a clinico-aetiological study of 864 cases in the perspective of a developing country.
MedLine Citation:
PMID:  18782317     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Chemical leucoderma, often clinically mimicking idiopathic vitiligo and other congenital and acquired hypopigmentation, has been increasing rapidly in incidence in developing countries such as India. OBJECTIVES: This study attempts to detect clinical and epidemiological patterns of chemical leucoderma. METHODS: Detailed history-taking, especially of exposure to contributory chemicals, clinical examination, relevant investigations, data recording and analysis were done. RESULTS: In a total of 864 cases of chemical leucoderma, 65.6% cases started de novo and vitiligo patches were pre-existing in the remaining cases. Patches were limited to the contact area in 73.7% but had spread to remote areas in 26.3% cases. The face (41.1%) and scalp (5.9%) were the commonest and least involved sites. Confetti macules were seen in 89% and pruritus was complained of in 21.8%. Aetiological agents identified were hair dye 27.4% (21% self-use; 6.4% not self-use), deodorant and spray perfume 21.6%, detergent and cleansers 15.4%, adhesive bindi 12%, rubber chappal 9.4%, black socks and shoes 9.1%, eyeliner 8.2%, lipliner 4.8%, rubber condoms 3.5%, lipstick 3.3%, fur toys 3.1%, toothpaste 1.9%, insecticides 1.7%, 'alta' 1.2%, amulet string colour 0.9%. Therapeutic response was much better in 'pure' chemical leucoderma (73.4%) than in those with co-existing vitiligo (20.9%). CONCLUSIONS: Chemical leucoderma, a disease of mostly industrial origin in developed countries, may be induced by common domestic products in developing countries. Diagnosis and differentiation from other causes of hypopigmentation can be done confidently by following the clinical criteria as proposed. The therapeutic response of chemical leucoderma is better than that of vitiligo.
S Ghosh; S Mukhopadhyay
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Publication Detail:
Type:  Journal Article     Date:  2008-09-06
Journal Detail:
Title:  The British journal of dermatology     Volume:  160     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-02-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  40-7     Citation Subset:  IM    
Department of Dermatology, Institute of Allergic and Immunologic Skin Diseases, 27/2 C Bakultala Lane, Kasba, Kolkata, West Bengal 700042, India.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Aged, 80 and over
Child, Preschool
Dermatitis, Occupational / epidemiology,  etiology,  pathology*
Diagnosis, Differential
Household Products / adverse effects
Hypopigmentation / chemically induced*,  epidemiology,  pathology
India / epidemiology
Middle Aged
PUVA Therapy / methods
Prospective Studies
Sex Distribution
Vitiligo / chemically induced,  epidemiology,  pathology
Young Adult
Reg. No./Substance:
0/Adrenal Cortex Hormones

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