Document Detail

Chemical lesion of the circumventricular organs with monosodium glutamate reduces the blood pressure of spontaneously hypertensive but not of one kidney-one clip hypertensive rats.
MedLine Citation:
PMID:  1342228     Owner:  NLM     Status:  MEDLINE    
Subcutaneous injection of monosodium glutamate (MSG) on days 1, 5 and 9 of the experiment (5 g/kg per day) significantly reduced the blood pressure of a group of 10 spontaneously hypertensive rats (SHR) measured 7 and 14 days after treatment (200 +/- 7 mmHg vs 172 +/- 8 mmHg or 185 +/- 3 mmHg, respectively), without affecting that of 11 age-matched Wistar Kyoto (WKY) rats (127 +/- 7 mmHg vs 123 +/- 5 mmHg and 119 +/- 5 mmHg, respectively). Using autoradiographic methods and 125I-Sar1-angiotensin II, receptor binding was shown to be higher in the subfornical organ (SFO) of SHR (332 +/- 31 fmol/mg protein) when compared to WKY rats (240 +/- 30 fmol/mg protein) and similar (222 +/- 21 vs 170 +/- 14 fmol/mg protein) in the paraventricular nucleus (PVN). Binding to angiotensin-converting enzyme (ACE) was evaluated using the ACE inhibitor 125I-351A as ligand. Binding to ACE was lower in SHR in the PVN and the globus pallidus (GP) of SHR when compared to WKY rats (PVN: 111 +/- 9 vs 172 +/- 13 and GP: 163 +/- 2 vs 213 +/- 7 fmol/mg protein) and similar in the SFO, choroid plexus (ChP) and caudate nucleus (CD) of both strains (SFO: 779 +/- 107 vs 805 +/- 169; ChP: 2,780 +/- 210 vs 3,140 +/- 360 and CD: 461 +/- 42 vs 424 +/- 18 fmol/mg protein). No changes in angiotensin II (Ang II) receptor number or binding to ACE were detected in these brain areas after MSG treatment of SHR or WKY rats.(ABSTRACT TRUNCATED AT 250 WORDS)
F M Corrêa; J M Saavedra
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  25     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1992  
Date Detail:
Created Date:  1994-02-10     Completed Date:  1994-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  515-9     Citation Subset:  IM    
Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
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MeSH Terms
Blood Pressure / drug effects*
Brain Chemistry / drug effects
Cerebral Ventricles / chemistry,  drug effects*,  physiopathology
Disease Models, Animal*
Hypertension, Renal / physiopathology*
Peptidyl-Dipeptidase A / analysis,  drug effects
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Wistar
Receptors, Angiotensin / analysis,  drug effects
Sodium Glutamate / pharmacology*
Time Factors
Reg. No./Substance:
0/Receptors, Angiotensin; 142-47-2/Sodium Glutamate; EC A

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