Document Detail


Chemical lesion of the circumventricular organs with monosodium glutamate reduces the blood pressure of spontaneously hypertensive but not of one kidney-one clip hypertensive rats.
MedLine Citation:
PMID:  1342228     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Subcutaneous injection of monosodium glutamate (MSG) on days 1, 5 and 9 of the experiment (5 g/kg per day) significantly reduced the blood pressure of a group of 10 spontaneously hypertensive rats (SHR) measured 7 and 14 days after treatment (200 +/- 7 mmHg vs 172 +/- 8 mmHg or 185 +/- 3 mmHg, respectively), without affecting that of 11 age-matched Wistar Kyoto (WKY) rats (127 +/- 7 mmHg vs 123 +/- 5 mmHg and 119 +/- 5 mmHg, respectively). Using autoradiographic methods and 125I-Sar1-angiotensin II, receptor binding was shown to be higher in the subfornical organ (SFO) of SHR (332 +/- 31 fmol/mg protein) when compared to WKY rats (240 +/- 30 fmol/mg protein) and similar (222 +/- 21 vs 170 +/- 14 fmol/mg protein) in the paraventricular nucleus (PVN). Binding to angiotensin-converting enzyme (ACE) was evaluated using the ACE inhibitor 125I-351A as ligand. Binding to ACE was lower in SHR in the PVN and the globus pallidus (GP) of SHR when compared to WKY rats (PVN: 111 +/- 9 vs 172 +/- 13 and GP: 163 +/- 2 vs 213 +/- 7 fmol/mg protein) and similar in the SFO, choroid plexus (ChP) and caudate nucleus (CD) of both strains (SFO: 779 +/- 107 vs 805 +/- 169; ChP: 2,780 +/- 210 vs 3,140 +/- 360 and CD: 461 +/- 42 vs 424 +/- 18 fmol/mg protein). No changes in angiotensin II (Ang II) receptor number or binding to ACE were detected in these brain areas after MSG treatment of SHR or WKY rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
F M Corrêa; J M Saavedra
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]     Volume:  25     ISSN:  0100-879X     ISO Abbreviation:  Braz. J. Med. Biol. Res.     Publication Date:  1992  
Date Detail:
Created Date:  1994-02-10     Completed Date:  1994-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8112917     Medline TA:  Braz J Med Biol Res     Country:  BRAZIL    
Other Details:
Languages:  eng     Pagination:  515-9     Citation Subset:  IM    
Affiliation:
Departamento de Farmacologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Brasil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoradiography
Blood Pressure / drug effects*
Brain Chemistry / drug effects
Cerebral Ventricles / chemistry,  drug effects*,  physiopathology
Disease Models, Animal*
Hypertension, Renal / physiopathology*
Peptidyl-Dipeptidase A / analysis,  drug effects
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Rats, Wistar
Receptors, Angiotensin / analysis,  drug effects
Sodium Glutamate / pharmacology*
Time Factors
Chemical
Reg. No./Substance:
0/Receptors, Angiotensin; 142-47-2/Sodium Glutamate; EC 3.4.15.1/Peptidyl-Dipeptidase A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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