Document Detail

Chemical identification of the sources of commercial Fructus Chebulae.
MedLine Citation:
PMID:  16042149     Owner:  NLM     Status:  MEDLINE    
Twenty-eight commercial samples of Fructus Chebulae were collected from local herbal markets in Taiwan and were determined to have been derived from Terminalia chebula Retz. and Terminalia chebula Retz. var. parviflora Thwaites, which differ markedly in external appearance. Ten tannin-related constituents [gallic acid (1), chebulic acid (2), punicalagin (4), chebulanin (7), corilagin (8), neochebulinic acid (9), ellagic acid (11), chebulagic acid (12), chebulinic acid (13) and 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (14)] were identified and quantified by HPLC. Samples derived from T. chebula. var. parviflora, which are typically round-shaped, generally contained higher concentrations of 13 and 14 but lower levels of 12 compared with those from T. chebula, which are largely oval-shaped. The ratio of the concentration of 14 to that of 4 may serve as a potential parameter for differentiating samples from the two origins (T. chebula, ratio 0.6 +/- 0.3; T. chebula. var. parviflora, ratio 3.4 +/- 2.2). Levels of the three major bioactive constituents 12-14 were found to provide good references for the quality assessment of Fructus Chebulae. The ratio of the concentration of 12 to that of 14 may offer a guideline for determining quality as well as origin of the drug (lower-grade T. chebula, ratio 12.4 +/- 6.0; medium-grade T. chebula, ratio 8.8 +/- 7.9; higher-grade T. chebula, ratio 3.2 +/- 0.8; T. chebula var. parviflora, ratio 1.6 +/- 0.7).
Lih-Jeng Juang; Shuenn-Jyi Sheu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Phytochemical analysis : PCA     Volume:  16     ISSN:  0958-0344     ISO Abbreviation:  Phytochem Anal     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-07-26     Completed Date:  2005-08-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9200492     Medline TA:  Phytochem Anal     Country:  England    
Other Details:
Languages:  eng     Pagination:  246-51     Citation Subset:  IM    
Department of Chemistry, National Taiwan Normal University, 88, Sec. 4, Tingchow Road, Taipei, Taiwan, Republic of China.
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MeSH Terms
Carboxylic Acids / chemistry,  isolation & purification*
Drugs, Chinese Herbal / analysis*
Fruit / chemistry
Tannins / chemistry,  isolation & purification*
Terminalia / chemistry*
Reg. No./Substance:
0/Carboxylic Acids; 0/Drugs, Chinese Herbal; 0/Tannins

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