Document Detail


Chemical evolution of biomolecule building blocks. Can thermodynamics explain the accumulation of glycine in the prebiotic ocean?
MedLine Citation:
PMID:  21431107     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It has always been a question of considerable scientific interest why amino acids (and other biomolecule building blocks) formed and accumulated in the prebiotic ocean. In this study, we suggest an answer to this question for the simplest amino acid, glycine. We have shown for the first time that classical equilibrium thermodynamics can explain the most likely selection of glycine (and the derivative of its dipeptide) in aqueous media, although glycine is not the lowest free energy structure among all (404) possible constitutional isomers. Species preceding glycine in the free energy order are either supramolecular complexes of small molecules or such molecules likely to dissociate and thus get back to the gas phase. Then, 2-hydroxyacetamide condensates yielding a thermodynamically favored derivative of glycine dipeptide providing an alternative way for peptide formation. It is remarkable that a simple equilibrium thermodynamic model can explain the accumulation of glycine and provide a reason for the importance of water in the formation process.
Authors:
Milán Szőri; Balázs Jójárt; Róbert Izsák; Kornél Szőri; Imre G Csizmadia; Béla Viskolcz
Related Documents :
18960507 - Cation-exchange behaviour of several elements in hydrobromic acid-organic solvent media.
7588517 - Direct determination of amino acids by capillary electrophoresis/electrochemistry using...
16402847 - Isotropic-nematic phase transition of single-walled carbon nanotubes in strong acids.
12830887 - Some factors affecting separation and detection of amino acids by high-performance anio...
2113907 - Brucella abortus 16s rrna and lipid a reveal a phylogenetic relationship with members o...
22146717 - Tobacco salicylic acid glucosyltransferase is active toward tuberonic acid (12-hydroxyj...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-22
Journal Detail:
Title:  Physical chemistry chemical physics : PCCP     Volume:  -     ISSN:  1463-9084     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888160     Medline TA:  Phys Chem Chem Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Chemical Informatics, Faculty of Education, University of Szeged, Boldogasszony sgt. 6, Szeged 6725, Hungary. milan@jgypk.u-szeged.hu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pattern formation in the Belousov-Zhabotinsky-PAMAM dendrimer system.
Next Document:  The predicted spectrum of the hypermetallic molecule MgOMg.