| Chemical etiology of nucleic acids: aminopropyl nucleic acids (APNAs). | |
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MedLine Citation:
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PMID: 17443886 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aminopropyl nucleic acids (APNAs) are constitutionally simple nucleic acid alternatives with one stereogenic center per nucleotide, and with the potential to hybridize with RNA and to exert catalytic functions. We have developed a protecting group strategy to synthesize APNAs, although in a not very efficient way. Isolation and purification of APNAs proved to be difficult. Their structures might be more suited to function as potential catalytic polymers than as information systems that may evolve into RNA. |
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Authors:
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Ding Zhou; Matheus Froeyen; Jozef Rozenski; Arthur Van Aerschot; Piet Herdewijn |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 4 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-25 Completed Date: 2007-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 740-61 Citation Subset: IM |
Affiliation:
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Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biogenesis* Indicators and Reagents Models, Molecular Molecular Conformation Nucleic Acids / chemistry* Oligonucleotides / chemistry Purines / chemistry Pyrimidines / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Indicators and Reagents; 0/Nucleic Acids; 0/Oligonucleotides; 0/Purines; 0/Pyrimidines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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