Document Detail


Chemical crosshairs on the central dogma.
MedLine Citation:
PMID:  17173017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As cellular machines and processes that regulate the flow of genomic information have come into sharper focus, a new level of chemical control has become possible. The scope of such chemical intervention extends from the mechanistic dissection of biochemical processes in living cells to the targeted control of gene networks and cell fate.
Authors:
Aseem Z Ansari
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Nature chemical biology     Volume:  3     ISSN:  1552-4450     ISO Abbreviation:  Nat. Chem. Biol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-17     Completed Date:  2007-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231976     Medline TA:  Nat Chem Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-7     Citation Subset:  IM    
Affiliation:
Genome Center of Wisconsin, Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA. ansari@biochem.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Enzyme Inhibitors / chemistry,  metabolism,  pharmacology
Humans
Ligands
Models, Biological
Models, Molecular
Molecular Structure
RNA Interference / drug effects,  physiology
RNA Polymerase II / antagonists & inhibitors,  chemistry*,  metabolism,  physiology*
Transcription, Genetic*
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Ligands; EC 2.7.7.-/RNA Polymerase II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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