Document Detail


Chemical control of hyperfibrinolytic states by synthetic inhibitors of fibrinolytic enzymes.
MedLine Citation:
PMID:  6605748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of two types of synthetic inhibitor of fibrinolytic enzymes (omega-aminocarboxylic acids, benzamidine derivatives) on intravascular fibrinolysis and fibrinogenolysis were studied in rats. Generalised primary fibrinogenolysis was produced by infusion of human plasminogen-streptokinase complex, secondary fibrinolysis was induced by infusion of the thrombin-like enzyme batroxobin. The inhibitors exerted different effects on the hyperfibrinolytic states. The omega-aminocarboxylic acids (PAMBA, AMCA) inhibited fibrinolysis more effective than fibrinogenolysis. In contrast, the benzamidines (APPA, NANP) were more potent inhibitors of fibrinogenolysis. Aprotinin examined for comparison behaved like the benzamidine derivatives.
Authors:
F Markwardt; H P Klöcking
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomedica biochimica acta     Volume:  42     ISSN:  0232-766X     ISO Abbreviation:  Biomed. Biochim. Acta     Publication Date:  1983  
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8304435     Medline TA:  Biomed Biochim Acta     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  725-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
4-Aminobenzoic Acid / analogs & derivatives,  pharmacology*
Amidines / pharmacology*
Aminobenzoic Acids / pharmacology*
Animals
Antifibrinolytic Agents / pharmacology*
Batroxobin / pharmacology
Benzamidines / pharmacology*
Cattle
Cyclohexanecarboxylic Acids / pharmacology*
Fibrinogen / metabolism*
Fibrinolysis / drug effects*
Humans
Kinetics
Rats
Structure-Activity Relationship
Thrombin / metabolism
Tranexamic Acid / pharmacology*
Chemical
Reg. No./Substance:
0/Amidines; 0/Aminobenzoic Acids; 0/Antifibrinolytic Agents; 0/Benzamidines; 0/Cyclohexanecarboxylic Acids; 1197-18-8/Tranexamic Acid; 150-13-0/4-Aminobenzoic Acid; 56-91-7/4-aminomethylbenzoic acid; 9001-32-5/Fibrinogen; EC 3.4.21.-/Batroxobin; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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