Document Detail

Chemical constituents of the red alga Laurencia tristicha.
MedLine Citation:
PMID:  17994390     Owner:  NLM     Status:  MEDLINE    
Six new sesquiterpenes, 10-hydroxy-epiaplysin (1), 10-hydroxy-aplysin (2), 10-hydroxy-debromoepiaplysin (3), aplysin-9-ene (4), epiaplysinol (5) and debromoepiaplysinol (6), together with 13 known compounds (7-19), have been isolated from the red alga Laurencia tristicha. The structures of 1-6 were determined by spectroscopic methods including IR, EI-MS, HREI-MS, and 1D and 2D NMR techniques. All compounds were obtained from this species for the first time and were tested for cytotoxic activities against several human cancer cell lines including lung adenocarcinoma (A549), stomach cancer (BGC-823), hepatoma (Bel 7402), colon cancer (HCT-8) and HeLa cell lines. Compound 6 showed selective cytotoxicity against HeLa cell line with IC(50) 15.5 microM, cholest-5-en-3beta,7alpha-diol (14) was toxic to all tested cell lines with IC(50) values of 16.8, 5.1, 0.5, 0.5, and 0.3 microM, respectively, and other compounds were inactive (IC(50)>10 microg/ml).
Jie Sun; Da-Yong Shi; Shuai Li; Su-Juan Wang; Li-Jun Han; Xiao Fan; Yong-Chun Yang; Jian-Gong Shi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of Asian natural products research     Volume:  9     ISSN:  1028-6020     ISO Abbreviation:  J Asian Nat Prod Res     Publication Date:    2007 Sep-Dec
Date Detail:
Created Date:  2007-11-12     Completed Date:  2008-05-14     Revised Date:  2009-07-21    
Medline Journal Info:
Nlm Unique ID:  100888334     Medline TA:  J Asian Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  725-34     Citation Subset:  IM    
Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
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MeSH Terms
Algae, Red / chemistry*
Cell Line, Tumor
Drug Screening Assays, Antitumor
Magnetic Resonance Spectroscopy
Molecular Structure
Spectrometry, Mass, Electrospray Ionization

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