| Chemical constituents and bioactivities of the liposoluble fraction from different medicinal parts of Crocus sativus. | |
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MedLine Citation:
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PMID: 21639689 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Context: Crocus sativus Linn. (Iridaceae), commonly known as saffron, becomes more and more popular due to its versatile biological and medicinal properties. At present, studies mainly focus on the traditional medicinal part, the saffron stigma, with less attention to the other parts of saffron, such as the perianth, the stamen, and the corm, which are high yield compared to the stigma and also possess various pharmacological effects. Objective: To determine the chemical compositions, antifungal, cytotoxic, and antioxidant activities of the ether fractions from the stamen, perianth, and stigma of saffron. Materials and methods: The chemical constituents of the ether fractions from different parts of saffron were investigated by gas chromatography/mass spectrometry. Several pathogenic fungi isolates and tumor cell lines were employed to evaluate the antifungal and cytotoxic activities of these three ether fractions. 1,1-Diphenyl-2-picrylhydrazyl assay was used to determine the free radical-scavenging activity. Results: The ether fractions composition of the three C. sativus parts are different from each other, but lauric acid, hexadecanoic acid, 4-hydroxydihydro-2(3H)-furanone, and stigmasterol were the common constituents shared by all the three fractions. The stamen ether fraction displayed the strongest antifungal and cytotoxic activities, whereas both of the saffron stamen and perianth ether fractions exhibited significant antioxidant activities. Discussion and conclusion: These findings demonstrate that the saffron stamen and perianth possess significant antifungal, cytotoxic, and antioxidant activities as well as the stigma, though not to the same extent, prompting us to expand the medicinal resource and make best use of this valuable plant. |
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Authors:
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Cheng-Jian Zheng; Lin Li; Wen-Hui Ma; Ting Han; Lu-Ping Qin |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pharmaceutical biology Volume: 49 ISSN: 1744-5116 ISO Abbreviation: Pharm Biol Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-06-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812552 Medline TA: Pharm Biol Country: England |
Other Details:
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Languages: eng Pagination: 756-63 Citation Subset: IM |
Affiliation:
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Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Guohe Road, Shanghai, PR China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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