| Chemical constituents of Heteroplexis micocephala. | |
| | |
MedLine Citation:
|
PMID: 19453174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Eleven new compounds including two sesquiterpenes with an unusual 2,2,5,9-tetramethylbicyclo[6.3.0]undecane carbon skeleton (1 and 2), five phytane-type diterpene dilactones (3-7), an ent-clerodane diterpene dilactone (8), and three phenylpropenol esters (9-11), together with a diacylphenol (12) and 38 known compounds, have been isolated from an ethanolic extract of Heteroplexis micocephala. Their structures including absolute configurations were elucidated by spectroscopic and chemical analyses. In the in vitro assays, compound 6 showed a selective cytotoxic activity against A2780 with an IC(50) value of 4.37 microM, while sinapyl diangelate (13) showed a potent activity inhibiting HIV-1 replication with an IC(50) value of 4.04 microM. |
| | |
Authors:
|
Xiaona Fan; Jiachen Zi; Chenggen Zhu; Wendong Xu; Wei Cheng; Sen Yang; Ying Guo; Jiangong Shi |
Related Documents
:
|
23215474 - First direct measurement of the ^{17}o(p,γ)^{18}f reaction cross section at gamow ener... 8258824 - Antioxidant and neutrophil-inhibiting properties of new 2-o-methyl-6-(alkylthio)ascorbi... 11428924 - Discovery of novel mesangial cell proliferation inhibitors using a three-dimensional da... 20353344 - Design, synthesis and anticholinesterase activity of some new α-aminobisphosphonates. 22732574 - On the potential increase of the oxidative stress status in patients with abdominal aor... 19860394 - One-pot facile synthesis of substituted isoindolinones via an ugi four-component conden... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Jun |
Date Detail:
|
Created Date: 2009-06-26 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
|
Languages: eng Pagination: 1184-90 Citation Subset: IM |
Affiliation:
|
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-HIV Agents
/
chemistry,
isolation & purification*,
pharmacology Asteraceae / chemistry* Diterpenes / chemistry, isolation & purification*, pharmacology Drug Screening Assays, Antitumor Drugs, Chinese Herbal / chemistry, isolation & purification*, pharmacology HIV-1 / drug effects Humans Inhibitory Concentration 50 Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plants, Medicinal / chemistry* Sesquiterpenes / chemistry, isolation & purification*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Anti-HIV Agents; 0/Diterpenes; 0/Drugs, Chinese Herbal; 0/Sesquiterpenes; 638-36-8/phytane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Thiopyrophosphoantigens: solid-phase synthesis and in vitro characterization of a new class of Vgamm...
Next Document: Visualizing Chemical Reactions and Crossover Processes in a Fuel Cell Inserted in the ESR Resonator:...