Document Detail

Chemical composition of normal and osteoarthrotic cancellous bone of the femoral head. Studies of EDTA extracts and collagenase digests.
MedLine Citation:
PMID:  6712429     Owner:  NLM     Status:  MEDLINE    
Using EDTA extraction and collagenase digestion, cancellous bone from the femoral heads of ten normal and eight osteoarthrotic individuals was analyzed for its content of collagen, sialoprotein, proteoglycan, and carbohydrate. The EDTA extractability of the matrix proteins of the osteoarthrotic bone was significantly increased (P less than 0.001), as was the soluble collagenase-resistant fraction (SCRF). EDTA residues, bone matrix size, the collagenase-resistant fraction (CRF), and the insoluble collagenase-resistant fraction (ICRF) of the osteoarthrotic cases were not different from those of the controls. The amounts of carbohydrate and proteoglycans were considerably elevated in the bone matrix of the osteoarthrotic bone (P less than 0.01 and P less than 0.001, respectively). In the EDTA extracts, sialoprotein and proteoglycan contents were found in significant higher amounts (P less than 0.05 and P less than 0.01, respectively) in the osteoarthrotic cases. In the SCRF, the hexose and sialic acid contents were higher in the osteoarthrotic bone (P less than 0.01), while in the ICRF all the analyses were significantly increased in the osteoarthrotic bone (P less than 0.001). The ratios of collagen to non-collagenous components were lower in the osteoarthrotic than in normal bones. The quantitative and qualitative variations in cancellous bone proteins from the femoral head in osteoarthrosis found in this study suggest that alterations in subchondral bone play a role in the pathophysiology of cartilage degeneration in osteoarthrosis.
J M Mbuyi-Muamba; J Dequeker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of orthopaedic and traumatic surgery. Archiv für orthopädische und Unfall-Chirurgie     Volume:  102     ISSN:  0344-8444     ISO Abbreviation:  Arch Orthop Trauma Surg     Publication Date:  1984  
Date Detail:
Created Date:  1984-05-18     Completed Date:  1984-05-18     Revised Date:  2008-02-21    
Medline Journal Info:
Nlm Unique ID:  7803037     Medline TA:  Arch Orthop Trauma Surg     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
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MeSH Terms
Collagen / metabolism
Electrophoresis, Polyacrylamide Gel
Femur Head / metabolism*
Hexoses / metabolism
Hydroxyproline / metabolism
Middle Aged
N-Acetylneuraminic Acid
Osteoarthritis / metabolism*
Proteins / metabolism*
Sialic Acids / metabolism
Uronic Acids / metabolism
Reg. No./Substance:
0/Hexoses; 0/Proteins; 0/Sialic Acids; 0/Uronic Acids; 131-48-6/N-Acetylneuraminic Acid; 51-35-4/Hydroxyproline; 9007-34-5/Collagen

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