Document Detail

Chemical composition, antimicrobial and antioxidant activities of the essential oil of Tibetan herbal medicine Dracocephalum heterophyllum Benth.
MedLine Citation:
PMID:  17999332     Owner:  NLM     Status:  MEDLINE    
The essential oil of Tibetan medicine Dracocephalum heterophyllum Benth was obtained by hydrodistillation with a 0.7% (v/w) yield. The chemical composition of the essential oil was analyzed by gas chromatography-mass spectral (GC-MS). Eighty-three compounds, constituting about 89.83% of the total oil, were identified. The main compound in the oil were Cineole (14.89%), trans-nerolido (7.10%), 1-m-ethyl-2-(1-methylethyl)-benzene (4.42%), Germacrene-D (4.84%), Decahydro-1,1,4,7-tetramethyl-4aH-cycloprop[e]azulen-4a-ol (4.94%), p-menth-1-en-4-ol,acetate (4.34%), 4-methyl-1-(1-methylethyl)-3-cyclohexen-1-ol (4.10%). The antimicrobial activity of the oil was evaluated against nine bacterial, one yeast, and three fungi. The antimicrobial test result showed that the essential oil strongly inhibited the growth of test microorganisms studied. The maximal inhibition zones and MIC values for bacterial, yeast and fungi strain were in the range of 18-25 mm and 0.039-0.156 mg mL(-1); *20 mm, and 0.156 mg mL(-1); 8-24 mm and 0.313-2.5 mg mL(-1); respectively. The antioxidant activity of the oil was determined by the malonyldialdehyde (MDA) test, measuring the MDA concentration in mouse liver cell microsomal after induced lipid peroxidation using FeSO(4) and ascorbic acid, The inhibition of lipid peroxidation was 59.3% with a concentration of 0.5 mg mL(-1). Result presented here may suggest that the essential oil of D. heterophyllum posses antimicrobial and antioxidant properties, and therefore, they can be one of new medicinal resources for antimicrobial agent and/or used as a natural preservative ingredient in food and cosmetics and pharmaceuticals industry.
Chunjiang Zhang; Hongyu Li; Tian Yun; Yonghong Fu; Chunmei Liu; Bu Gong; Benjia Neng
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Natural product research     Volume:  22     ISSN:  1478-6419     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-11-13     Completed Date:  2008-04-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
School of Life Science, Lanzhou University, Lanzhou, China.
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MeSH Terms
Anti-Infective Agents / chemistry*,  pharmacology*
Antioxidants / chemistry*,  pharmacology*
Bacteria / drug effects
Fungi / drug effects
Herbal Medicine
Lamiaceae / chemistry*
Oils, Volatile / chemistry,  pharmacology
Plant Oils / chemistry*,  pharmacology*
Reg. No./Substance:
0/Anti-Infective Agents; 0/Antioxidants; 0/Oils, Volatile; 0/Plant Oils

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