Document Detail

Chemical composition and anti-stress effects of yeast hydrolysate.
MedLine Citation:
PMID:  20041782     Owner:  NLM     Status:  MEDLINE    
In the present study, the anti-stress effects of yeast hydrolysate (YH) were investigated. The YH consisted of crude carbohydrate (23.6%) and crude protein (68.3%) with low contents of crude ash (3.1%) and crude fat (0.3%). Also, acidic amino acids (glutamic acid + aspartic acid) were present in large quantities (14.2 and 5.0 mol%, respectively). Pronase digestion had little effect on the affinity of the YH on 5-hydroxytryptamine (serotonin) and norepinephrine transporters, whereas NaIO(4) oxidation of the hydrolysate decreased the affinity by about 10% at 1,000 microg/mL, indicating that the periodate-labile carbohydrate moiety played a leading role in the affinity effects of the carbohydrate in YH. As a result of brain mapping after the administration of the YH for 3 days in human subjects, a symmetrical distribution of theta and alpha waves in the central and parietal lobes was observed. This brain mapping pattern of theta and alpha wave distribution appears in a psychologically stable state. The YH groups showed improvements in Beck Depression Inventory and Beck Anxiety Inventory scores after YH administration for 2 weeks. Treatment also seemed to have a more significant (P < .05) impact on the somatic manifestations of anxiety as indexed by the Beck Anxiety Inventory scores. Food materials used as a source of YH have been found to be associated with increases in alertness and adaptation to stress.
Hyun-Sun Lee; Eun Young Jung; Hyung Joo Suh
Publication Detail:
Type:  Clinical Trial, Phase III; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of medicinal food     Volume:  12     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-31     Completed Date:  2010-03-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1281-5     Citation Subset:  IM    
Research Institute of Health Sciences, Korea University, Seoul, Republic of Korea.
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MeSH Terms
Anxiety / drug therapy
Brain Mapping
Middle Aged
Saccharomyces cerevisiae / chemistry*
Stress, Psychological / drug therapy*,  psychology
Yeast, Dried / administration & dosage*,  chemistry

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