Document Detail

Chemical composition, anti-inflammatory, molluscicidal and free-radical scavenging activities of the leaves of Ficus radicans 'Variegata' (Moraceae).
MedLine Citation:
PMID:  21424983     Owner:  NLM     Status:  MEDLINE    
The methanol crude extract of the leaves of Ficus radicans Roxb. 'Variegata' (Moraceae) and the n-hexane, ethyl acetate and aqueous methanol fractions resulting from its fractionation were evaluated for their anti-inflammatory, molluscicidal and free-radical scavenging activities. The crude extract and fractions exhibited significant inhibition of inflammation in both croton oil (CO)-induced ear oedema in mice (p<0.001) and carrageenan-induced rat paw oedema models (p<0.01). The molluscicidal assay against Biomphalaria glabrata showed a weak activity for the n-hexane fraction (DL(50)= 400 µg mL(-1)). A moderated 1,1-diphenyl-1-picrylhydrazyl (DPPH) free-radical scavenging activity was observed for the ethyl acetate fraction (IC(50)= 66.2 µg mL(-1)). Fractionation of the extracts through chromatographic methods afforded the coumarins 7-methoxycoumarin, 7-hydroxy-6-methoxycoumarin and methoxy-3,4-dihydrocoumarin, the steroids β-sitosterol and β-sitosterol 3-O-β-glucopyranoside, as well as a cinnamic acid derivative and a flavonoid identified as trans-4-methoxy-2-β-D-glucopyranosyloxy cinnamic acid and quercetin 3-O-β-D-xylopyranosyl-(1 → 2)-α-L-rhamnopyranoside, respectively. The compounds were identified on the basis of their NMR spectral data and comparison with those previously reported in the literature.
Maria Augusta Naressi; Marcos Alessandro dos Santos Ribeiro; Ciomar Aparecida Bersani-Amado; Maria Lucilia M Zamuner; Willian Ferreira da Costa; Clara M Abe Tanaka; Maria Helena Sarragiotto
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Publication Detail:
Type:  Journal Article     Date:  2011-06-21
Journal Detail:
Title:  Natural product research     Volume:  26     ISSN:  1478-6427     ISO Abbreviation:  Nat. Prod. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-07     Completed Date:  2012-08-10     Revised Date:  2012-09-10    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
Programa de Pós-Graduação, Departamento de Química, Universidade Estadual de Maringá, Maringá-PR, Brazil.
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MeSH Terms
Anti-Inflammatory Agents / chemistry,  pharmacology*
Biomphalaria / drug effects
Biphenyl Compounds / metabolism
Carrageenan / toxicity
Cinnamates / chemistry,  pharmacology*
Croton Oil / toxicity
Drug Evaluation, Preclinical / methods
Edema / chemically induced,  drug therapy
Ficus / chemistry*
Free Radical Scavengers / pharmacology*
Glucosides / chemistry,  isolation & purification
Molecular Structure
Molluscacides / chemistry,  pharmacology*
Monosaccharides / chemistry,  pharmacology*
Picrates / metabolism
Plant Extracts / chemistry,  pharmacology
Plant Leaves / chemistry
Quercetin / analogs & derivatives*,  chemistry,  pharmacology
Rats, Wistar
Scopoletin / chemistry
Sitosterols / chemistry,  isolation & purification
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Biphenyl Compounds; 0/Cinnamates; 0/Free Radical Scavengers; 0/Glucosides; 0/Molluscacides; 0/Monosaccharides; 0/Picrates; 0/Plant Extracts; 0/Sitosterols; 0/quercetin 3-O-beta-D-xylopyranosyl-(1-2)-alpha-L-rhamnopyranoside; 0/sitosterol-3-O-glucopyranoside; 0/trans-4-methoxy-2-beta-D-glucopyranosyloxycinnamic acid; 117-39-5/Quercetin; 1898-66-4/2,2-diphenyl-1-picrylhydrazyl; 5779-62-4/sitosterol; 8001-28-3/Croton Oil; 9000-07-1/Carrageenan; 92-61-5/Scopoletin

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