Document Detail

Chemical characterization of a family of brain lipids that induce sleep.
MedLine Citation:
PMID:  7770779     Owner:  NLM     Status:  MEDLINE    
A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results suggest that fatty acid primary amides may represent a previously unrecognized class of biological signaling molecules.
B F Cravatt; O Prospero-Garcia; G Siuzdak; N B Gilula; S J Henriksen; D L Boger; R A Lerner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  268     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-07-05     Completed Date:  1995-07-05     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1506-9     Citation Subset:  IM    
Department of Chemistry, Scripps Research Institute, La Jolla, CA 92307, USA.
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MeSH Terms
Brain Chemistry*
Cerebrosides / cerebrospinal fluid*,  chemistry,  pharmacology
Lipids / cerebrospinal fluid*,  chemistry,  pharmacology
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Weight
Oleic Acids / cerebrospinal fluid*,  chemistry,  pharmacology
Signal Transduction
Sleep* / drug effects
Spectrometry, Mass, Fast Atom Bombardment
Spectrophotometry, Infrared
Grant Support
1 S10 RR07273-01/RR/NCRR NIH HHS
Reg. No./Substance:
0/Cerebrosides; 0/Lipids; 0/Oleic Acids; 301-02-0/oleylamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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