Document Detail

Chemical characterization of acylpolyamine toxins from venom of a trap-door spider and two tarantulas.
MedLine Citation:
PMID:  2389254     Owner:  NLM     Status:  MEDLINE    
Two acylpolyamines are identified from venom of the trap-door spider, Hebestatis theveniti. These toxins (paralytic to lepidopteran insect larvae) are amides containing 3-(3-indolyl)lactic acid joined to spermine or 1,13-diamino-4,10-diazatridecane (Het389 and Het403, respectively). Het389 is also abundant in venom from a tarantual from Mozambique (Harpactirella sp.). Two additional acylpolyamines (Apc600 and Apc728) are partially characterized from venom of another tarantula, Aphonopelma chalcodes.
W S Skinner; P A Dennis; A Lui; R L Carney; G B Quistad
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  28     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1990  
Date Detail:
Created Date:  1990-09-27     Completed Date:  1990-09-27     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  IM    
Sandoz Crop Protection Corporation, Research Division, Palo Alto, CA 94304.
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MeSH Terms
Arthropod Venoms / analysis*
Chemical Phenomena
Chromatography, High Pressure Liquid
Indoles / pharmacology
Larva / drug effects
Lepidoptera / drug effects
Mass Spectrometry
Molecular Weight
Polyamines / pharmacology
Spermine / analogs & derivatives,  pharmacology
Spider Venoms / analysis*
Toxins, Biological*
Reg. No./Substance:
0/Arthropod Venoms; 0/Het 389 toxin; 0/Het 403 toxin; 0/Indoles; 0/Polyamines; 0/Spider Venoms; 0/Toxins, Biological; 71-44-3/Spermine

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