Document Detail


Chemical characterisation and cytotoxic effects in A549 cells of urban-air PM10 collected in Torino, Italy.
MedLine Citation:
PMID:  21787597     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Human type II alveolar cells (A549) were exposed to aqueous- and organic-solvent PM10 extracts to evaluate their effects on cell proliferation, proinflammatory cytokine release and cytotoxicity (assayed by lactate dehydrogenase, LDH, activity). PM10 samples collected in Torino (northwest Italy) were analysed for inorganic chemical species (bioavailable iron and secondary particulates) and endotoxins, which are potentially inflammatory promoters in human airways. During the sampling period, PM10 concentration was 55.4±39.1μg/m(3), secondary particles constituted 42±9% of the PM10 total mass, and bioavailable iron concentration was 0.078±0.095μg/m(3). PM10 inhibits cell proliferation and induces both IL-6 and LDH release in a dose- and time-dependent manner, with a seasonal trend. The different effects of aqueous and organic PM10 extracts demonstrate the importance of particle composition for the induction of cytotoxic effects on A549 cells. A first comparison between the biological effects induced by PM10 extracts and PM10 components was performed.
Authors:
Tiziana Schilirò; Luca Alessandria; Raffaella Degan; Deborah Traversi; Giorgio Gilli
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Publication Detail:
Type:  Journal Article     Date:  2010-01-06
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  29     ISSN:  1872-7077     ISO Abbreviation:  Environ. Toxicol. Pharmacol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2011-07-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  150-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Affiliation:
Department of Public Health and Microbiology, University of Torino, Via Santena 5bis, 10126 Torino, Italy.
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