Document Detail

Chemical cardiomyopathies: the negative effects of medications and nonprescribed drugs on the heart.
MedLine Citation:
PMID:  21605722     Owner:  NLM     Status:  MEDLINE    
The heart is a target of injury for many chemical compounds, both medically prescribed and not medically prescribed. Pathophysiologic mechanisms underlying the development of chemical-induced cardiomyopathies vary depending on the inciting agent, including direct toxic effects, neurohormonal activation, altered calcium homeostasis, and oxidative stress. Numerous chemicals and drugs are implicated in cardiomyopathy. This article discusses examples of medication and nonprescribed drug-induced cardiomyopathies and reviews their pathophysiologic mechanisms.
Vincent M Figueredo
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  124     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-24     Completed Date:  2011-07-18     Revised Date:  2012-01-04    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  480-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Einstein Institute for Heart and Vascular Health, Albert Einstein Medical Center, Jefferson Medical College, Philadelphia, PA, USA.
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MeSH Terms
Amphetamine / adverse effects
Anabolic Agents / adverse effects
Anthracyclines / adverse effects
Antineoplastic Agents / adverse effects
Cardiomyopathies / chemically induced*,  mortality,  physiopathology*
Chloroquine / adverse effects
Clozapine / adverse effects
Cocaine / adverse effects
Doxorubicin / adverse effects
Ephedra / adverse effects
Ethanol / adverse effects
Heart / drug effects*,  physiopathology
Methylphenidate / adverse effects
Nonprescription Drugs / adverse effects*
Prescription Drugs / adverse effects*
Testosterone / adverse effects
Reg. No./Substance:
0/Anabolic Agents; 0/Anthracyclines; 0/Antineoplastic Agents; 0/Nonprescription Drugs; 0/Prescription Drugs; 113-45-1/Methylphenidate; 23214-92-8/Doxorubicin; 300-62-9/Amphetamine; 50-36-2/Cocaine; 54-05-7/Chloroquine; 5786-21-0/Clozapine; 58-22-0/Testosterone; 64-17-5/Ethanol
Comment In:
Am J Med. 2011 Dec;124(12):e15; author reply e17   [PMID:  22114837 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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