Document Detail

Chemical bladder irritation provokes c-fos expression in the midbrain periaqueductal gray matter of the rat.
MedLine Citation:
PMID:  12650968     Owner:  NLM     Status:  MEDLINE    
We investigated the topographical localization of c-fos expression in the midbrain periaqueductal gray matter (PAG) to detect nociception-induced neural activity in the PAG. In conscious female Wistar rats, c-fos expression was induced by continuous intravesical infusion of saline or 0.1% acetic acid. Number of c-fos protein (Fos)-positive cells was counted at each coronal section of the PAG as well as Barrington's nucleus. Fos-positive cells were also counted at L1 and L6 of the spinal cord, where most of the hypogastric and pelvic nerve afferent terminals project, respectively. Compared with saline infusion, acetic acid infusion provoked irritative bladder responses characterized by a marked increase in the frequency of bladder contractions, and induced a significant increase in the number of Fos-positive cells in both L1 and L6 of the spinal cord. Following acetic acid infusion, there was a significant increase in the number of Fos-positive cells in all coronal sections of the PAG compared with saline infusion, especially in the caudal part of the PAG. The increase in the number of Fos-positive cells was mainly observed in the ventrolateral and lateral parts of the caudal PAG, and in the dorsal part of the rostral PAG. However, there was no difference in the number of Fos-positive cells in Barrington's nucleus between saline and acetic acid infusion. In conclusion, nociception induced by chemical bladder irritation influences neural activity in the PAG. Implication of topographical difference in Fos expression in the PAG and its relevance to changes in bladder function remain to be elucidated.
Takahiko Mitsui; Hidehiro Kakizaki; Shinobu Matsuura; Hiroshi Tanaka; Mitsuhiro Yoshioka; Tomohiko Koyanagi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Brain research     Volume:  967     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-03-24     Completed Date:  2003-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  81-8     Citation Subset:  IM    
Department of Urology, Hokkaido University Graduate School of Medicine, North-15, West-7, Kita-ku, Sapporo 060-8638, Japan.
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MeSH Terms
Acetic Acid / toxicity
Gene Expression Regulation / drug effects,  physiology
Mesencephalon / drug effects,  metabolism
Periaqueductal Gray / drug effects,  metabolism*
Proto-Oncogene Proteins c-fos / biosynthesis*
Rats, Wistar
Stimulation, Chemical
Urinary Bladder / drug effects*,  metabolism*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-fos; 64-19-7/Acetic Acid

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