Document Detail


Chemical and biological characterization of different Tc complexes of cysteine and cysteine derivatives.
MedLine Citation:
PMID:  660286     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The labeling of cysteine and its derivatives (penicillamine, N-acetylcysteine, cysteine ethyl ester) with 99Tc (99mTc) was studied as a model for the radiopharmaceutical preparation of Tc-99m mercaptide complexes. After the use of TcO4-, TcOCl52-, and TcBr62- as labeling agents for the Tc oxidation states VII, V, and IV, respectively, complexes of Tc(V) and Tc(IV) were prepared and characterized. The biologic behavior of these complexes was studied in rats. The substitutions in cysteine are responsible for substantial changes of net charge and lipophilicity in the Tc complexes, and the consequences on the excretion patterns in Wistar rats are discussed.
Authors:
B Johannsen; R Syhre; H Spies; R Münze
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  19     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1978 Jul 
Date Detail:
Created Date:  1978-09-01     Completed Date:  1978-09-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  816-24     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / diagnostic use*,  metabolism
Animals
Cysteine / diagnostic use*,  metabolism
Isotope Labeling
Male
Penicillamine / diagnostic use*,  metabolism
Rats
Technetium / diagnostic use*
Tissue Distribution
Chemical
Reg. No./Substance:
52-67-5/Penicillamine; 52-90-4/Cysteine; 616-91-1/Acetylcysteine; 7440-26-8/Technetium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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