Document Detail

Chemical aversion therapy in the treatment of cocaine dependence as part of a multimodal treatment program: treatment outcome.
MedLine Citation:
PMID:  2313768     Owner:  NLM     Status:  MEDLINE    
A pilot feasibility study of chemical aversion therapy in the treatment of cocaine dependence as part of a multimodal treatment program was conducted at the Schick Shadel Hospital of Santa Barbara. Twenty (20) patients (9 treating for cocaine only and 11 treating for cocaine/alcohol), who primarily snorted cocaine, completed a program which included chemical aversion therapy to develop a conditioned aversion to the sight, smell, and taste of a cocaine substitute (tetracaine, mannitol, and quinine with Psychem. Ninety-five (95) percent of patients were followed up in six months with a total abstinence rate from cocaine of 56% (78% current abstinence of at least 30 days prior to follow-up) in the cocaine only group and total abstinence from cocaine of 70% (also 70% current abstinence) for the cocaine/alcohol group. Ninety (90) percent were followed up at 18 months. Thirty eight (38) percent of the cocaine only group had been totally abstinent (75% were currently abstinent). Fifty (50) percent of the cocaine/alcohol group had been totally abstinent (80% were currently abstinent). Validation of results was obtained from "significant others" for 90% of patients.
P J Frawley; J W Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of substance abuse treatment     Volume:  7     ISSN:  0740-5472     ISO Abbreviation:  J Subst Abuse Treat     Publication Date:  1990  
Date Detail:
Created Date:  1990-04-26     Completed Date:  1990-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8500909     Medline TA:  J Subst Abuse Treat     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  21-9     Citation Subset:  IM    
Schick Shadel Hospital, Santa Barbara, California 93105.
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MeSH Terms
Administration, Inhalation
Alcoholism / rehabilitation*
Aversive Therapy / methods*
Combined Modality Therapy
Emetine / therapeutic use
Follow-Up Studies
Injections, Intramuscular
Pilot Projects
Substance-Related Disorders / rehabilitation*
Tetracaine / therapeutic use*
Reg. No./Substance:
483-18-1/Emetine; 50-36-2/Cocaine; 94-24-6/Tetracaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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