Document Detail


Chemical approaches to study metabolic networks.
MedLine Citation:
PMID:  23296751     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One of the more provocative realizations that have come out of the genome sequencing projects is that organisms possess a large number of uncharacterized or poorly characterized enzymes. This finding belies the commonly held notion that our knowledge of cell metabolism is nearly complete, underscoring the vast landscape of unannotated metabolic and signaling networks that operate under normal physiological conditions, let alone in disease states where metabolic networks may be rewired, dysregulated, or altered to drive disease progression. Consequently, the functional annotation of enzymatic pathways represents a grand challenge for researchers in the post-genomic era. This review will highlight the chemical technologies that have been successfully used to characterize metabolism, and put forth some of the challenges we face as we expand our map of metabolic pathways.
Authors:
Daniel Medina-Cleghorn; Daniel K Nomura
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-08
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  465     ISSN:  1432-2013     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-27     Completed Date:  2013-08-13     Revised Date:  2014-03-07    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  427-40     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Enzyme Inhibitors / pharmacology
Humans
Metabolic Networks and Pathways*
Metabolomics / methods*
Protein Array Analysis
Proteome / antagonists & inhibitors,  metabolism
Grant Support
ID/Acronym/Agency:
R00 DA030908/DA/NIDA NIH HHS; R00DA030908/DA/NIDA NIH HHS; R21 CA170317/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 0/Proteome
Comments/Corrections

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