| Chemical Synthesis of Helicobacter pylori Lipopolysaccharide Partial Structures and their Selective Proinflammatory Responses. | |
| | |
MedLine Citation:
|
PMID: 22095469 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Helicobacter pylori is a common cause of gastroduodenal inflammatory diseases such as chronic gastritis and peptic ulcers and also an important factor in gastric carcinogenesis. Recent reports have demonstrated that bacterial inflammatory processes, such as stimulation with H. pylori lipopolysaccharide (LPS), initiate atherosclerosis. To establish the structures responsible for the inflammatory response of H. pylori LPS, we synthesized various kinds of lipid A structures (i.e., triacylated lipid A and Kdo-lipid A compounds), with or without the ethanolamine group at the 1-phosphate moiety, by a new divergent synthetic route. Stereoselective α-glycosylation of Kdo N-phenyltrifluoroacetimidate was achieved by use of microfluidic methods. None of the lipid A and Kdo-lipid A compounds were a strong inducer of IL-1β, IL-6, or IL-8, suggesting that H. pylori LPS is unable to induce acute inflammation. In fact, the lipid A and Kdo-lipid A compounds showed antagonistic activity against cytokine induction by E. coli LPS, except for the lipid A compound with the ethanolamine group, which showed very weak agonistic activity. On the other hand, these H. pylori LPS partial structures showed potent IL-18- and IL-12-inducing activities. IL-18 has been shown to correlate with chronic inflammation, so H. pylori LPS might be implicated in the chronic inflammatory responses induced by H. pylori. These results also indicated that H. pylori LPS can modulate the immune response: NF-κB activation through hTLR4/MD-2 was suppressed, whereas production of IL-18 and IL-12 was promoted. |
| | |
Authors:
|
Atsushi Shimoyama; Akinori Saeki; Natsuko Tanimura; Hiroko Tsutsui; Kensuke Miyake; Yasuo Suda; Yukari Fujimoto; Koichi Fukase |
Related Documents
:
|
9714209 - Location of induction and expression of protective immunity against fasciola hepatica a... 20203509 - Mast cells and mastocytosis. 15333729 - Maternal adaptive immunity influences the intestinal microflora of suckling mice. 18497709 - Prevention of hemorrhagic shock-induced intestinal tissue injury by glutamine via heme ... 20150509 - In vivo actin cross-linking induced by vibrio cholerae type vi secretion system is asso... 15591589 - Glucocorticoid responsiveness in developing human intestine: possible role in preventio... 21037099 - Cutting edge: mechanisms of il-2-dependent maintenance of functional regulatory t cells. 22346749 - The arabidopsis lectin receptor kinase lecrk-v.5 represses stomatal immunity induced by... 14597229 - Pdnf, a human parasite-derived mimic of neurotrophic factors, prevents caspase activati... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
|
Title: Chemistry (Weinheim an der Bergstrasse, Germany) Volume: - ISSN: 1521-3765 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9513783 Medline TA: Chemistry Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Department of Chemistry, Graduate School of Science, Osaka University, Toyonaka, Osaka 560-0043 (Japan), Fax: (+81) 6-6850-5419. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determination and pharmacokinetics of [6]-gingerol in mouse plasma by liquid chromatography-tandem m...
Next Document: 1?,25(OH)(2) D(3) -dependent modulation of Akt in proliferating and differentiating C2C12 skeletal ...