| Chemical synthesis of 9(Z)-octadecenamide and its hypolipidemic effect: a bioactive agent found in the essential oil of mountain celery seeds. | |
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MedLine Citation:
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PMID: 20078072 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The unusual hypolipidemic activity of the methanolic fractionate of the essential oil (EOM) obtained from the mountain celery seed was previously reported. The most enriched 9(Z)-octadecenamide (oleamide) was speculated to be responsible for the relevant bioactivity. Chemically syntheized oleamide (CSO) yielded 85.1% with a purity of 98.6% when identified by RP-HPLC, FTIR, HREIMS, (1)H NMR, and (13)C NMR. CSO was tested for its antioxidative and hypolipidemic bioactivities. Results indicated CSO was potently hypolipidemic with regard to serum TG, TC, LDL-C, LDL-C/HDL-C, and hepatic TG (p < 0.05), but not for serum HDL-C and hepatic TC. In addition, CSO exhibited only poor antioxidative activity, implicating the possibility that the hypolipidemic and antioxidative bioactivity of original EOM was due to another coexisting constituent, probably gamma-selinene. Conclusively, oleamide is a potent hypolipidemic agent as regarding its effects on decreasing serum TG, TC, LDL-C and hepatic TG. |
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Authors:
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Ming-Ching Cheng; Yaw-Bee Ker; Tung-Hsi Yu; Li-Yun Lin; Robert Y Peng; Chiung-Huei Peng |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 58 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-03 Completed Date: 2010-04-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 1502-8 Citation Subset: IM |
Affiliation:
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Graduate Institute of Bioindustrial Technology, Da-Yeh University, 112 Shan-Jiao Road, Dah-Tsuen County, Changhua Hsien, Taiwan 515. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antilipemic Agents / administration & dosage*, chemical synthesis, chemistry Apium graveolens / chemistry* Cricetinae Disease Models, Animal Humans Hyperlipidemias / drug therapy*, metabolism Lipid Metabolism / drug effects Male Mesocricetus Oils, Volatile / administration & dosage, pharmacology Oleic Acids / administration & dosage*, chemical synthesis, chemistry Plant Oils / administration & dosage, chemical synthesis, chemistry Random Allocation Seeds / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antilipemic Agents; 0/Oils, Volatile; 0/Oleic Acids; 0/Plant Oils; 301-02-0/oleylamide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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