| Chemical stability of new acyclovir analogues with peptidomimetics. | |
| | |
MedLine Citation:
|
PMID: 21773064 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
In the search for new and effective prodrugs against the herpes simplex virus, a series of acyclovir analogues with a thiazole ring containing amino acids (glycine, alanine, valine, leucine) has been investigated. The chemical stability of some of the compounds containing different residues was studied at pH 1 and pH 7.4 at a temperature of 37°C. An HPLC method was developed for quantification of the unchanged ester concentration.Some of the esters (Gly-thiazole, Ala-thiazole-acyclovir, Leu-thiazole-acyclovir) were rather unstable, especially under acidic conditions, and underwent rapid hydrolysis into the chemical precursor acyclovir. At pH 7.4, the stability of Valthiazole-acyclovir was remarkable. At this pH, Val-thiazole-acyclovir showed stability higher than that of valacyclovir (the first effective prodrug of acyclovir). |
| | |
Authors:
|
Georgi Hristov; Ivanka Stankova |
Related Documents
:
|
9147124 - The effect of areca nut on salivary and selected oral microorganisms. 4984174 - Growth and sporulation of bacillus subtilis mutants blocked in the pyruvate dehydrogena... 16887614 - Comparison of batch culture growth and fermentation of a poultry veillonella isolate an... 21926224 - Species diversity, community dynamics, and metabolite kinetics of the microbiota associ... 21088224 - The novel udp glycosyltransferase 3a2: cloning, catalytic properties, and tissue distri... 3031274 - Binding of [3h]3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid to rat brain membran... |
Publication Detail:
|
Type: Journal Article Date: 2011-03-05 |
Journal Detail:
|
Title: Scientia pharmaceutica Volume: 79 ISSN: 2218-0532 ISO Abbreviation: Sci Pharm Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-07-20 Completed Date: 2011-11-10 Revised Date: 2011-11-10 |
Medline Journal Info:
|
Nlm Unique ID: 0026251 Medline TA: Sci Pharm Country: Austria |
Other Details:
|
Languages: eng Pagination: 259-64 Citation Subset: - |
Affiliation:
|
Department of Chemistry, South-West University 'Neofit Rilski', Ivan Michailov str. 66, 2700 Blagoevgrad, Bulgaria. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Models for the prediction of receptor tyrosine kinase inhibitory activity of substituted 3-aminoinda...
Next Document: Preparation and quality control of the [sm]-samarium maltolate complex as a lanthanide mobilization ...