| Chemical Mapping of Pharmaceutical Cocrystals Using Terahertz Spectroscopic Imaging. | |
| | |
MedLine Citation:
|
PMID: 23351123 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Terahertz (THz) spectroscopic imaging is a promising technique for distinguishing pharmaceuticals of similar molecular composition but differing crystal structures. Physicochemical properties, for instance bioavailability, are manipulated by altering a drug's crystal structure through methods such as cocrystallisation. Cocrystals are molecular complexes having crystal structures different from those of their pure components. A technique for identifying the two-dimensional distribution of these alternate forms is required. Here we present the first demonstration of THz spectroscopic imaging of cocrystals. THz spectra of caffeine-oxalic acid cocrystal measured at low temperature exhibit sharp peaks, enabling us to visualize the cocrystal distribution in non-uniform tablets. The cocrystal distribution was clearly identified using THz spectroscopic data, and the cocrystal concentration was calculated with 0.3-1.3 % w/w error from the known total concentration. From this result, THz spectroscopy allows quantitative chemical mapping of cocrystals, and offers researchers and drug developers a new analytical tool. |
| | |
Authors:
|
Danielle Marie Charron; Katsuhiro Ajito; Jae-Young Kim; Yuko Ueno |
Related Documents
:
|
10422853 - Comparison of recording systems and analysis methods in specular microscopy. 16369093 - The integration of macromolecular diffraction data. 1178873 - Initial clinical evaluation of a new ultrasonic camera. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-28 |
Journal Detail:
|
Title: Analytical chemistry Volume: - ISSN: 1520-6882 ISO Abbreviation: Anal. Chem. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370536 Medline TA: Anal Chem Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dementia knowledge transfer project in a rural area.
Next Document: Why join groups? Lessons from parasite-manipulated Artemia.