Document Detail


Chemical Composition and Biological Evaluation of Physalis peruviana Root as Hepato-renal Protective Agent.
MedLine Citation:
PMID:  23419022     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
ABSTRACT This study was designed to investigate the potential of Physalis peruviana root as a functional food with hepato-renal protective effects against fibrosis. The chemical composition of the plant root suggested the presence of alkaloids, withanolides and flavonoids. Five compounds were isolated and their structures elucidated by different spectral analysis techniques. One compound was isolated from the roots: cuscohygrine. The biological evaluation was conducted on different animal groups; control rats, control treated with ethanolic root extract, CCl(4) group, CCl(4) treated with root extract, and CCl(4) treated with silymarin as a standard herbal drug. The evaluation used the oxidative stress markers malondialdehyde (MDA), superoxide dismutase (SOD), and nitric oxide (NO). The liver function indices; aspartate and alanine aminotransferases (AST & ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), bilirubin, and total hepatic protein were also estimated. Kidney disorder biomarkers; creatinine, urea, and serum protein were also evaluated. The results suggested safe administration, and improvement of all the investigated parameters. The liver and kidney histopathological analysis confirmed the results. In conclusion, P. peruviana succeeded in protecting the liver and kidney against fibrosis. Further studies are needed to discern their pharmacological applications and clinical uses.
Authors:
Souad E El-Gengaihi; Emad E Hassan; Manal A Hamed; Hanan G Zahran; Mona A Mohammed
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dietary supplements     Volume:  10     ISSN:  1939-022X     ISO Abbreviation:  J Diet Suppl     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101249830     Medline TA:  J Diet Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  39-53     Citation Subset:  IM    
Affiliation:
1Department of Medicinal & Aromatic Plants.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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