Document Detail

Chemical Composition and Antifungal Activity of Cuminum cyminum L. Essential Oil From Alborz Mountain Against Aspergillus species.
MedLine Citation:
PMID:  24624154     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Aflatoxin B1 (AFB1) is a highly toxic and hepatocarcinogenic metabolite produced by Aspergillus species. Some natural products are known to kill fungi and destroy toxins and toxin-producing agents.
OBJECTIVES: The purpose of this study is to provide experimental data on the antifungal activity of cumin oils and their components that could be considered suitable for application in foods and drugs.
MATERIALS AND METHODS: The essential oil (EO) of Cuminum cyminum L. collected from Alborz Mountain, Iran, was obtained by hydro-distillation. The oil was analyzed by gas chromatography (GC) and chromatography/mass spectrophotometry (GC/MS). The antifungal activity of the oil was studied with regard to the inhibition of the growth of Aspergillus flavus PICC-AF39 , Aspergillus flavus PICC-AF24, Aspergillus parasiticus NRRL-2999 and Aspergillus niger. The minimal inhibitory (MIC) and minimal fungicidal (MFC) concentrations of the oil were determined.
RESULTS: α-Pinene (29.2%), limonene (21.7%), 1,8-cineole (18.1%), linalool (10.5%), linalyl acetate (4.8%), and α-terpineole (3.17%) were the major components of the essential oil from C. cyminum L., and the oil showed a strong inhibitory effect on fungal growth.
CONCLUSIONS: Essential oils could be safely used as preservatives in pharmaceuticals as well as health and food products to protect them against toxigenic fungal infections.
Hossein Mohammadpour; Eskandar Moghimipour; Iraj Rasooli; Mohammad Hadi Fakoor; Shakiba Alipoor Astaneh; Sara Shehni Moosaie; Zeynab Jalili
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Publication Detail:
Type:  Journal Article     Date:  2012-05-28
Journal Detail:
Title:  Jundishapur journal of natural pharmaceutical products     Volume:  7     ISSN:  1735-7780     ISO Abbreviation:  Jundishapur J Nat Pharm Prod     Publication Date:  2012  
Date Detail:
Created Date:  2014-03-13     Completed Date:  2014-03-13     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  101585019     Medline TA:  Jundishapur J Nat Pharm Prod     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  -    
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