Document Detail


Chemerin regulates proliferation and differentiation of myoblast cells via ERK1/2 and mTOR signaling pathways.
MedLine Citation:
PMID:  22906999     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Obesity in human is an alarming major public health crisis worldwide and insulin resistance is a hallmark of it. The negative cross-talk between skeletal muscle and adipose tissue through adipokines is now accepted as one of the leading cause of insulin resistance. Chemerin is a novel adipokine previously reported to induce insulin resistance in primary human skeletal muscle cells. To investigate the role of chemerin in myogenesis, C2C12 cells were used and treated with chemerin in proliferation and differentiation stages. Our results showed that chemerin promoted proliferation and suppressed differentiation of C2C12 cells through extracellular-signal regulated kinase-1/2 (ERK1/2) and mammalian target of rapamycin (mTOR) signaling pathways, and these two pathways were interacted with each other in C2C12 cells treated with chemerin. It is concluded from this in vitro study that chemerin which expression is increased during myoblast differentiation appears to be able, likely in an autocrine/paracrine manner, to increase myoblast proliferation and decrease myoblast differentiation.
Authors:
Huansheng Yang; Fengna Li; Xiangfeng Kong; Xiaoxue Yuan; Wence Wang; Ruilin Huang; Tiejun Li; Meimei Geng; Guoyao Wu; Yulong Yin
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-17
Journal Detail:
Title:  Cytokine     Volume:  -     ISSN:  1096-0023     ISO Abbreviation:  Cytokine     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9005353     Medline TA:  Cytokine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Hunan Engineering and Research Center of Animal and Poultry Science and Key Laboratory of Agro-Ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha Hunan 410125, China; Graduate School of the Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of Animal Nutrition, China Agricultural University, Beijing 100193, China.
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