Document Detail


Chelation in metal intoxication XXX: Alpha-mercapto-beta-aryl acrylic acids as antidotes to cadmium toxicity.
MedLine Citation:
PMID:  2748547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
alpha-Mercapto-beta-(2-furyl) acrylic acid (MFA), alpha-mercapto-beta-(2-hydroxyphenyl) acrylic acid (MHA), beta-1,2-phenylene di-alpha-mercaptoacrylic acid (1,2-PDMA) and beta-1,4-phenylene di-alpha-mercapto acrylic acid (1,4-PDMA) were compared to sodium N-benzyl-D-glucamine dithiocarbamate (NBG-DTC) an effective cadmium chelator, for their ability to mobilize Cd and influence the Cd induced tissue metallothionein (MT) in rats administered 109CdCl2, 72 hr earlier. MFA was almost as effective as NBG-DTC but more effective than MHA in enhancing urinary and faecal excretion of Cd, reducing tissue and blood levels of Cd and in lowering Cd induced increase in hepatic and renal MT contents. 1,2-PDMA and 1,4-PDMA were effective only in reducing the hepatic burden of Cd. The resuls do not indicate any direct relationship between the efficacy of alpha-mercapto-beta-aryl acrylic acids to decorporate body Cd and their lipophilic-hydrophilic character or number-arrangement of their sulfhydryl groups.
Authors:
S K Tandon; B L Sharma; D N Kachru
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pharmacology & toxicology     Volume:  64     ISSN:  0901-9928     ISO Abbreviation:  Pharmacol. Toxicol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-08-15     Completed Date:  1989-08-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8702180     Medline TA:  Pharmacol Toxicol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  380-2     Citation Subset:  IM    
Affiliation:
Industrial Toxicology Research Centre, Lucknow, India.
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MeSH Terms
Descriptor/Qualifier:
Acrylates / therapeutic use*
Animals
Antidotes*
Cadmium / pharmacokinetics
Cadmium Poisoning / drug therapy*
Chelating Agents / therapeutic use*
Feces / analysis
Female
Metallothionein / metabolism
Rats
Sulfhydryl Compounds / therapeutic use*
Tissue Distribution
Chemical
Reg. No./Substance:
0/Acrylates; 0/Antidotes; 0/Chelating Agents; 0/Sulfhydryl Compounds; 7440-43-9/Cadmium; 9038-94-2/Metallothionein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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