| Chelation of hypocrellin B with zinc ions with electron paramagnetic resonance (EPR) evidence of the photodynamic activity of the resulting chelate. | |
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MedLine Citation:
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PMID: 11767412 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypocrellin B (HB), a perylenequinone derivative, is an efficient phototherapeutic agent. The chelation of HB with Zinc ions (Zn2+) results in a metal chelate (Zn-HB) which exhibits considerable absorption (lambda max = 612 nm) in the phototherapeutic window. The structure of this chelate has been characterized by UV-Vis, IR and mass spectra. The redox potentials of the Zn-HB chelate were Eox = +1.1 V (vs. SCE) and Ere = -0.7 V (vs. SCE) as measured using the circle volt curve. The quantum yield of singlet oxygen generated by the Zn-HB chelate was 0.86, which both the electron spin trap (EPR) method and the chemical trap method show to be about 0.1 higher than that of its parent compound HB. In irradiated oxygen-saturated solutions of Zn-HB chelate, superoxide radical anions and hydroxyl radicals were detected by EPR spectroscopy using 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) as the spin-trapping agent. |
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Authors:
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C Tian; S Xu; S Chen; J Shen; M Zhang; T Shen |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical research Volume: 35 ISSN: 1071-5762 ISO Abbreviation: Free Radic. Res. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-12-20 Completed Date: 2002-02-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 543-54 Citation Subset: IM |
Affiliation:
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Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100080, P.R. China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Chelating Agents Electrochemistry Electron Spin Resonance Spectroscopy Humans Hydroxyl Radical / chemistry Molecular Structure Perylene / analogs & derivatives*, chemistry*, pharmacology* Photochemotherapy Photosensitizing Agents / chemistry*, pharmacology* Quinones / chemistry*, pharmacology* Spectrometry, Fluorescence Spectrophotometry Spectrophotometry, Infrared Superoxides / chemistry Zinc |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Photosensitizing Agents; 0/Quinones; 11062-77-4/Superoxides; 123940-54-5/hypocrellin B; 198-55-0/Perylene; 3352-57-6/Hydroxyl Radical; 7440-66-6/Zinc |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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