| Chelating agents in biological systems. | |
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MedLine Citation:
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PMID: 6791916 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Chelation enables metals to be transported to or from vulnerable target sites, and to hinder or facilitate their carcinogenic potential. In the reverse sense, metals are capable of ligand scavenging via complexation or mixed complex formation--the latter being the result of interaction with binary complexes. Consequently, metal complexes can be utilized for the transport of selected organic chemotherapeutic drugs to target organs, or for the decorporation of those toxic organic compounds which are able, before or after metabolic activation, of reacting with metals or 1:1 metal complexes. It is emphasized that the degree to which metal ions interact in vivo should employ the conditional constants which take into account competition from other ions, especially Ca2+, H+, and OH-. The genotoxic consequences of the various chemical factors involved in chelation, along with examples: kinetics, stabilization of oxoidation states, lipophilicity, and mixed ligand formation, are discussed. |
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Authors:
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J Schubert |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Environmental health perspectives Volume: 40 ISSN: 0091-6765 ISO Abbreviation: Environ. Health Perspect. Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-11-22 Completed Date: 1981-11-22 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0330411 Medline TA: Environ Health Perspect Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 227-32 Citation Subset: IM |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / drug effects Catalase / metabolism Chelating Agents / metabolism* Edetic Acid / metabolism Kinetics Metals / metabolism* Oxidation-Reduction |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 0/Metals; 60-00-4/Edetic Acid; EC 1.11.1.6/Catalase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Environ Health Perspect ISSN: 0091-6765 |
Article Information Download PDF  Print publication date: Month: 8 Year: 1981 Volume: 40First Page: 227 Last Page: 232 ID: 1568836 PubMed Id: 6791916 |
| Chelating agents in biological systems. | |
| J Schubert | |
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