| Chasing fate and function of new neurons in adult brains. | |
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MedLine Citation:
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PMID: 11240289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuron production, migration and differentiation are major developmental events that continue, on a smaller scale, into adult life in a wide range of species from insects to mammals. Recent reports of adult neurogenesis in primates, including humans, have led to explosive scientific and public attention. During the last two years, significant discoveries have revealed that the generation, recruitment and survival of new neurons in adult brains are governed by principles similar to those that shape the developing brain, such as neuronal death, sensory experience, activity levels, and learning. Similarly, many factors implicated in embryonic neurogenesis are increasingly found to regulate adult neurogenesis and survival as well. These findings now allow the first manipulations of the numbers of adult-generated neurons to address their potential behavioral function. |
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Authors:
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C Scharff |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in neurobiology Volume: 10 ISSN: 0959-4388 ISO Abbreviation: Curr. Opin. Neurobiol. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-05-17 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9111376 Medline TA: Curr Opin Neurobiol Country: England |
Other Details:
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Languages: eng Pagination: 774-83 Citation Subset: IM |
Affiliation:
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The Rockefeller University, 1230 York Avenue Box 137, New York, NY 10021, USA. scharfc@rockvax.rockefeller.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Brain / cytology* Neurons / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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