| Charge selectivity of proteinuria in type I diabetes explored by Ig subclass clearance. | |
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MedLine Citation:
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PMID: 1756909 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate the role of protein charge in early diabetic proteinuria, the clearance of proteins differing in charge and/or size (anionic and cationic Igs, albumin) was evaluated in 98 insulin-dependent (type I) diabetic patients selected as a representative sample of the 418 patients attending our clinics. Of the patients, 12.9% were microalbuminuric and 4.8% were macroalbuminuric. Anionic and total IgG clearances were significantly increased in 30.6 and 12.2% of patients and were correlated with duration of disease. Anionic IgG4 clearances were increased in patients (9.2%) with normal IgG excretion, suggesting that charge-selectivity impairment is responsible for protein loss. Anionic Ig clearances were also higher in some patients (14.3%) with normal albumin clearance, probably as a result of different glomerular filtration and/or tubular reabsorption. The anionic-cationic IgG clearance ratio tended to increase in parallel with albumin clearance, but once above macroalbuminuric levels, it tended to fall again, indicating the concomitant presence of size-selectivity loss. The anionic IgG clearance and the anionic-cationic IgG ratio, in addition to albumin excretion, may be valuable in assessing early kidney protein charge-selectivity impairment and better characterizing normoalbuminuric patients and those in the preclinical stage of diabetic nephropathy. |
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Authors:
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P Pietravalle; S Morano; G Cristina; M G De Rossi; G Mariani; P Cotroneo; G Ghirlanda; A Clementi; D Andreani; U Di Mario |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetes Volume: 40 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1991 Dec |
Date Detail:
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Created Date: 1992-02-03 Completed Date: 1992-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1685-90 Citation Subset: AIM; IM |
Affiliation:
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Department of Endocrinology, University La Sapienza, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Albuminuria* Biological Markers / urine Diabetes Mellitus, Type 1 / immunology, physiopathology, urine* Diabetic Nephropathies / diagnosis Follow-Up Studies Glomerular Filtration Rate Humans Immunoglobulin G / classification, urine* Metabolic Clearance Rate Models, Statistical Proteinuria* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Immunoglobulin G |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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