| Characterizing stiffness of human prostates using acoustic radiation force. | |
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MedLine Citation:
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PMID: 21213566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acoustic Radiation Force Impulse (ARFI) imaging has been previously reported to portray normal anatomic structures and pathologies in ex vivo human prostates with good contrast and resolution. These findings were based on comparison with histological slides and McNeal's zonal anatomy. In ARFI images, the central zone (CZ) appears darker (smaller displacement) than other anatomic zones and prostate cancer (PCa) is darker than normal tissue in the peripheral zone (PZ). Since displacement amplitudes in ARFI images are determined by both the underlying tissue stiffness and the amplitude of acoustic radiation force that varies with acoustic attenuation, one question that arises is how the relative displacements in prostate ARFI images are related to the underlying prostatic tissue stiffness. In linear, isotropic elastic materials and in tissues that are relatively uniform in acoustic attenuation (e.g., liver), relative displacement in ARFI images has been shown to be correlated with underlying tissue stiffness. However, the prostate is known to be heterogeneous. Variations in acoustic attenuation of prostatic structures could confound the interpretation of ARFI images due to the associated variations in the applied acoustic radiation force. Therefore, in this study, co-registered three-dimensional (3D) ARFI datasets and quantitative shear wave elasticity imaging (SWEI) datasets were acquired in freshly-excised human prostates to investigate the relationship between displacement amplitudes in ARFI prostate images and the matched reconstructed shear moduli. The lateral time-to-peak (LTTP) algorithm was applied to the SWEI data to compute the shear-wave speed and reconstruct the shear moduli. Five types of prostatic tissue (PZ, CZ, transition zone (TZ) and benign prostatic hyperplasia (BPH), PCa and atrophy) were identified, whose shear moduli were quantified to be 4.1 +/- 0.8 kPa, 9.9 +/- 0.9 kPa, 4.8 +/- 0.6 kPa, 10.0 +/- 1.0 kPa and 8.0 kPa, respectively. Linear regression was performed to compare ARFI displacement amplitudes and the inverse of the corresponding reconstructed shear moduli at multiple depths. The results indicate an inverse relation between ARFI displacement amplitude and reconstructed shear modulus at all depths. These findings support the conclusion that ARFI prostate images portray underlying tissue stiffness variations. |
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Authors:
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Liang Zhai; John Madden; Wen-Chi Foo; Vladimir Mouraviev; Thomas J Polascik; Mark L Palmeri; Kathryn R Nightingale |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Ultrasonic imaging Volume: 32 ISSN: 0161-7346 ISO Abbreviation: Ultrason Imaging Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2011-01-07 Completed Date: 2011-02-03 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 7909167 Medline TA: Ultrason Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 201-13 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA. liang.zhai@duke.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Elastic Modulus* Elasticity Imaging Techniques / methods* Humans Image Processing, Computer-Assisted / methods Imaging, Three-Dimensional / methods Male Prostate / ultrasonography* Prostatic Diseases / ultrasonography Prostatic Neoplasms / ultrasonography* Reproducibility of Results |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA-114075/CA/NCI NIH HHS; R01 CA114075/CA/NCI NIH HHS; R01 CA142824/CA/NCI NIH HHS; R01 EB002132/EB/NIBIB NIH HHS |
| Comments/Corrections | |
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