Document Detail


Characterizing dementia with Lewy bodies by means of diffusion tensor imaging.
MedLine Citation:
PMID:  22895591     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate patterns of in vivo white matter tract change using diffusion tensor imaging (DTI), we conducted a cross-sectional study of dementia with Lewy bodies (DLB) in comparison with Alzheimer disease (AD) and normal aging.
METHODS: The study included 106 subjects (35 with DLB, 36 with AD, and 35 elderly controls) who underwent clinical and neuropsychological assessment and diffusion tensor MRI. We used tract-based spatial statistics to investigate patterns of reduced fractional anisotropy (FA) and increased mean diffusivity (MD) across the entire white matter tract skeleton and also investigated correlations with clinical features.
RESULTS: Areas of reduced FA in subjects with DLB vs controls were found primarily in parieto-occipital white matter tracts; in AD, the changes were much more diffuse. DLB was also associated with reduced FA in the pons and left thalamus, in comparison with AD. The pattern of MD increase was diffuse in AD and DLB. We found an association between DTI parameters and impaired episodic memory, letter fluency, and severity of motor parkinsonism in DLB.
CONCLUSIONS: Despite a similar level of dementia severity, patterns of DTI changes in AD and DLB differed significantly. The selective involvement of the visual association areas and subcortical structures and the significant clinical correlations highlight the potential importance of white matter tract change in the pathogenesis of DLB. DTI may be a useful technique to investigate early and possible preclinical changes in DLB and warrants further investigation.
Authors:
Rosie Watson; Andrew M Blamire; Sean J Colloby; Josh S Wood; Robert Barber; Jiabao He; John T O'Brien
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-08-15
Journal Detail:
Title:  Neurology     Volume:  79     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-28     Completed Date:  2012-11-07     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  906-14     Citation Subset:  AIM; IM    
Affiliation:
Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne, UK. rosie.watson@ncl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / pathology
Anisotropy
Cerebral Cortex / pathology
Diffusion Tensor Imaging / methods*
Female
Humans
Image Processing, Computer-Assisted
Lewy Body Disease / pathology*
Male
Memory, Episodic
Neuropsychological Tests
Parkinson Disease / complications,  physiopathology
Pons / pathology
Psychomotor Performance / physiology
Pyramidal Tracts / pathology
Thalamus / pathology
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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