| Characterizing brain oxygen metabolism in patients with multiple sclerosis with T2-relaxation-under-spin-tagging MRI. | |
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MedLine Citation:
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PMID: 22252237 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, venous oxygen saturation and oxygen metabolic changes in multiple sclerosis (MS) patients were assessed using a recently developed T2-relaxation-under-spin-tagging (TRUST) magnetic resonance imaging (MRI), which measures the superior sagittal venous sinus blood oxygenation (Yv) and cerebral metabolic rate of oxygen (CMRO(2)), an index of global oxygen consumption. Thirty patients with relapsing-remitting MS and 30 age-matched healthy controls were studied using TRUST at 3 T MR. The mean expanded disability status scale (EDSS) of the patients was 2.3 (range, 0 to 5.5). We found significantly increased Yv (P<0.0001) and decreased CMRO(2) (P=0.003) in MS patients (mean±s.d.: 65.9%±5.1% and 138.8±35.4 μmol per 100 g per minute) as compared with healthy control subjects (60.2%±4.0% and 180.2±24.8 μmol per 100 g per minute, respectively), implying decrease of oxygen consumption in MS. There was a significant positive correlation between Yv and EDSS and between Yv and lesion load in MS patients (n=30); on the contrary, there was a significant negative correlation between CMRO(2) and EDSS and between CMRO(2) and lesion load (n=12). There was no correlation between Yv and brain atrophy measures. This study showed preliminary evidence of the potential utility of TRUST in global oxygen metabolism. Our results of significant underutilization of oxygen in MS raise important questions regarding mitochondrial respiratory dysfunction and neurodegeneration of the disease. |
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Authors:
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Yulin Ge; Zhongwei Zhang; Hanzhang Lu; Lin Tang; Hina Jaggi; Joseph Herbert; James S Babb; Henry Rusinek; Robert I Grossman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-01-18 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 32 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-01 Completed Date: 2012-04-23 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 403-12 Citation Subset: IM |
Affiliation:
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Department of Radiology, Center for Biomedical Imaging, New York University School of Medicine, New York, New York 10016, USA. yulin.ge@nyumc.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain / blood supply, metabolism*, pathology Case-Control Studies Cerebrovascular Circulation / physiology Data Interpretation, Statistical Female Humans Magnetic Resonance Spectroscopy / methods* Male Middle Aged Multiple Sclerosis, Relapsing-Remitting / metabolism*, pathology, physiopathology Oxygen / metabolism* Oxygen Consumption* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH084021/MH/NIMH NIH HHS; R01 NS067015/NS/NINDS NIH HHS; R01NS029029/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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7782-44-7/Oxygen |
| Comments/Corrections | |
Comment In:
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J Cereb Blood Flow Metab. 2012 Mar;32(3):401-2
[PMID:
22214902
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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