Document Detail


Characterizing the assembly behaviors of human amylin: a perspective derived from C-terminal variants.
MedLine Citation:
PMID:  23146899     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The differences in the C-terminal domains of human amylin peptide variants initiate different aggregation processes and differences in the composition of the aggregates by affecting the hydrophobic cores, conformations, and intra-sheet interactions of the peptides, which have distinct effects on the cytotoxicity of the peptides.
Authors:
Mei-Sha Chen; De-Sheng Zhao; Ye-Ping Yu; Wei-Wei Li; Yong-Xiang Chen; Yu-Fen Zhao; Yan-Mei Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Chemical communications (Cambridge, England)     Volume:  -     ISSN:  1364-548X     ISO Abbreviation:  Chem. Commun. (Camb.)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610838     Medline TA:  Chem Commun (Camb)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China. liym@mail.tsinghua.edu.cn.
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