Document Detail

Characterizing Preclinical Model of Ischemic Heart Failure: Difference Between LAD and LCx Infarctions.
MedLine Citation:
PMID:  25217654     Owner:  NLM     Status:  Publisher    
Background: Large animal studies are an important step towards clinical translation of novel therapeutic approaches. We aimed to establish an ischemic heart failure (HF) model with a larger myocardial infarction (MI) relative to previous studies, and characterize the functional and structural features of this model. Methods: An MI was induced by occluding the proximal left anterior descending artery (LAD, n=15) or the proximal left circumflex artery (LCx, n=6) in Yorkshire pigs. Three pigs with sham procedures were also included. All pigs underwent hemodynamic and echocardiographic assessments before MI, at 1 month, and 3 months after MI. Analyses of left ventricular (LV) myocardial mechanics by means of strains and torsion were performed using speckle-tracking echocardiography and compared between the groups. Results: The proximal LAD MI approach induced larger infarct sizes (14.2±3.2% vs 10.6±1.9%, P=0.03), depressed systolic function (LVEF; 39.8±7.5% vs 54.1±4.6%, P<0.001), and more LV remodeling (end-systolic volume index; 82±25 ml/m(2) vs 51±18 ml/m(2), P=0.02, LAD vs LCx, respectively) compared to the LCx MI approach without compromising the survival rate. At the papillary muscle level, echocardiographic strain analysis revealed no differences in radial and circumferential strain between LAD and LCx MIs. However, in contrast to the LCx MI, the LAD MI resulted in significantly decreased longitudinal strain. Conclusion: The proximal LAD MI model induces more LV remodeling and depressed LV function relative to the LCx MI model. Location of MI significantly impacts the severity of HF, thus careful consideration is required when choosing an MI model for preclinical HF studies.
Kiyotake Ishikawa; Jaume Aguero; Lisa Tilemann; Dennis Ladage; Nadjib Hammoudi; Yoshiaki Kawase; Carlos G Santos-Gallego; Kenneth Fish; Robert A Levine; Roger J Hajjar
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-12
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  -     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013, American Journal of Physiology - Heart and Circulatory Physiology.
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